Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications
<i>Background and Objectives</i>: Hyperopia is a refractive error which affects cognitive and social development if uncorrected and raises the risk of primary angle-closure glaucoma (PACG). <i>Materials and Methods</i>: The study included only the right eye—40 hyperopic eyes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/9/1660 |
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| author | Maria-Cristina Marinescu Dana-Margareta-Cornelia Dascalescu Mihaela-Monica Constantin Valeria Coviltir Vasile Potop Dan Stanila Farah Constantin Cristina Alexandrescu Radu-Constantin Ciuluvica Liliana-Mary Voinea |
| author_facet | Maria-Cristina Marinescu Dana-Margareta-Cornelia Dascalescu Mihaela-Monica Constantin Valeria Coviltir Vasile Potop Dan Stanila Farah Constantin Cristina Alexandrescu Radu-Constantin Ciuluvica Liliana-Mary Voinea |
| author_sort | Maria-Cristina Marinescu |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Hyperopia is a refractive error which affects cognitive and social development if uncorrected and raises the risk of primary angle-closure glaucoma (PACG). <i>Materials and Methods</i>: The study included only the right eye—40 hyperopic eyes in the study group (spherical equivalent (SE) under pharmacological cycloplegia over 0.50 D), 34 emmetropic eyes in the control group (SE between −0.50 D and +0.50 D). A complete ophthalmological evaluation was performed, including autorefractometry to measure SE, and additionally we performed Ocular Response Analyser: Corneal Hysteresis (CH), Corneal Resistance Factor (CRF); specular microscopy: Endothelial cell density (CD), Cell variability (CV), Hexagonality (Hex), Aladdin biometry: Anterior Chamber Depth (ACD), Axial Length (AL), Central Corneal Thickness (CCT). IBM SPSS 26 was used for statistical analysis. <i>Results</i>: The mean age of the entire cohort was 22.93 years (SD ± 12.069), 66.22% being female and 33.78% male. The hyperopic eyes had significantly lower AL, ACD, higher SE, CH, CRF. In the hyperopia group, there are significant, negative correlations between CH and AL (r −0.335), CRF and AL (r −0.334), SE–AL (r −0.593), ACD and CV (r −0.528), CV and CRF (r −0.438), CH (r −0.379), and positive correlations between CCT and CH (r 0.393) or CRF (r 0.435), CD and ACD (r 0.509) or CH (0.384). Age is significantly, negatively correlated with ACD (r −0.447), CH (r −0.544), CRF (r −0.539), CD (r −0.546) and positively with CV (r 0.470). <i>Conclusions</i>: Our study suggests a particular biomechanical behavior of the cornea in hyperopia, in relation with morphological and endothelial parameters. Moreover, the negative correlation between age and ACD suggests a shallower anterior chamber as patients age, increasing the risk for PACG. |
| first_indexed | 2024-03-10T22:29:22Z |
| format | Article |
| id | doaj.art-c8e65f6dfb6044a9a6705f4c74c2d02e |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T22:29:22Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj.art-c8e65f6dfb6044a9a6705f4c74c2d02e2023-11-19T11:53:05ZengMDPI AGMedicina1010-660X1648-91442023-09-01599166010.3390/medicina59091660Particular Anatomy of the Hyperopic Eye and Potential Clinical ImplicationsMaria-Cristina Marinescu0Dana-Margareta-Cornelia Dascalescu1Mihaela-Monica Constantin2Valeria Coviltir3Vasile Potop4Dan Stanila5Farah Constantin6Cristina Alexandrescu7Radu-Constantin Ciuluvica8Liliana-Mary Voinea9Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Ophthalmology, Oftaclinic, 040254 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Ophthalmology, Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, RomaniaDepartment of Ophthalmology, Faculty of Medicine, Ovidius University, 900470 Constanta, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania<i>Background and Objectives</i>: Hyperopia is a refractive error which affects cognitive and social development if uncorrected and raises the risk of primary angle-closure glaucoma (PACG). <i>Materials and Methods</i>: The study included only the right eye—40 hyperopic eyes in the study group (spherical equivalent (SE) under pharmacological cycloplegia over 0.50 D), 34 emmetropic eyes in the control group (SE between −0.50 D and +0.50 D). A complete ophthalmological evaluation was performed, including autorefractometry to measure SE, and additionally we performed Ocular Response Analyser: Corneal Hysteresis (CH), Corneal Resistance Factor (CRF); specular microscopy: Endothelial cell density (CD), Cell variability (CV), Hexagonality (Hex), Aladdin biometry: Anterior Chamber Depth (ACD), Axial Length (AL), Central Corneal Thickness (CCT). IBM SPSS 26 was used for statistical analysis. <i>Results</i>: The mean age of the entire cohort was 22.93 years (SD ± 12.069), 66.22% being female and 33.78% male. The hyperopic eyes had significantly lower AL, ACD, higher SE, CH, CRF. In the hyperopia group, there are significant, negative correlations between CH and AL (r −0.335), CRF and AL (r −0.334), SE–AL (r −0.593), ACD and CV (r −0.528), CV and CRF (r −0.438), CH (r −0.379), and positive correlations between CCT and CH (r 0.393) or CRF (r 0.435), CD and ACD (r 0.509) or CH (0.384). Age is significantly, negatively correlated with ACD (r −0.447), CH (r −0.544), CRF (r −0.539), CD (r −0.546) and positively with CV (r 0.470). <i>Conclusions</i>: Our study suggests a particular biomechanical behavior of the cornea in hyperopia, in relation with morphological and endothelial parameters. Moreover, the negative correlation between age and ACD suggests a shallower anterior chamber as patients age, increasing the risk for PACG.https://www.mdpi.com/1648-9144/59/9/1660hyperopiaemmetropiacorneal hysteresiscorneal resistance factorendothelial cell densityendothelial cell variability |
| spellingShingle | Maria-Cristina Marinescu Dana-Margareta-Cornelia Dascalescu Mihaela-Monica Constantin Valeria Coviltir Vasile Potop Dan Stanila Farah Constantin Cristina Alexandrescu Radu-Constantin Ciuluvica Liliana-Mary Voinea Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications Medicina hyperopia emmetropia corneal hysteresis corneal resistance factor endothelial cell density endothelial cell variability |
| title | Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications |
| title_full | Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications |
| title_fullStr | Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications |
| title_full_unstemmed | Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications |
| title_short | Particular Anatomy of the Hyperopic Eye and Potential Clinical Implications |
| title_sort | particular anatomy of the hyperopic eye and potential clinical implications |
| topic | hyperopia emmetropia corneal hysteresis corneal resistance factor endothelial cell density endothelial cell variability |
| url | https://www.mdpi.com/1648-9144/59/9/1660 |
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