Mapping the genetic landscape of early-onset Alzheimer’s disease in a cohort of 36 families

Mapping the genetic landscape of early-onset Alzheimer’s disease in a cohort of 36 families

Abstract Background Many families with clinical early-onset Alzheimer’s disease (EOAD) remain genetically unexplained. A combination of genetic factors is not standardly investigated. In addition to monogenic causes, we evaluated the possible polygenic architecture in a large series of families, to...

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Bibliographic Details
Main Authors: Merel O. Mol, Sven J. van der Lee, Marc Hulsman, Yolande A. L. Pijnenburg, Phillip Scheltens, Netherlands Brain Bank, Harro Seelaar, John C. van Swieten, Laura Donker Kaat, Henne Holstege, Jeroen G. J. van Rooij
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Early-onset Alzheimer disease
Familial Alzheimer disease
Whole exome sequencing
Genetic testing
Genetic counseling
Online Access:https://doi.org/10.1186/s13195-022-01018-3

Internet

https://doi.org/10.1186/s13195-022-01018-3

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