Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis

Abstract Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studies have examined the role of CatD in the development of Aβ pathology an...

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Bibliographic Details
Main Authors: Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Tauopathy
Neurofibrillary tangles
Amyloid-β protein
Cathepsin D
Alzheimer disease
Lysosomes
Online Access:https://doi.org/10.1186/s13195-024-01443-6

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