The alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression
Abstract Intersectin 1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which are highly regulated by alternative splicing. Our previous results showed that the two isoforms of ITSN1 displayed opposite functions: ITSN1-S promoted glioma development, while ITSN1-L exerted an inhibitory role in gli...
Main Authors: | Chungen Lan, Huikun Zhang, Kezhen Wang, Xiaoli Liu, Yawen Zhao, Zhifang Guo, Ning Zhang, Yongxia Zhou, Manzhi Gao, Feng Gu, Yongjie Ma |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2022-09-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-022-05238-1 |
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