NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortex
Abstract Spinal cord injury (SCI) may cause structural alterations in brain due to pathophysiological processes, but the effects of SCI treatment on brain have rarely been reported. Here, voxel-based morphometry is employed to investigate the effects of SCI and neurotrophin-3 (NT3) coupled chitosan-...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-09981-5 |
| _version_ | 1819210087900643328 |
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| author | Shu-Sheng Bao Can Zhao Hao-Wei Chen Ting Feng Xiao-Jun Guo Meng Xu Jia-Sheng Rao |
| author_facet | Shu-Sheng Bao Can Zhao Hao-Wei Chen Ting Feng Xiao-Jun Guo Meng Xu Jia-Sheng Rao |
| author_sort | Shu-Sheng Bao |
| collection | DOAJ |
| description | Abstract Spinal cord injury (SCI) may cause structural alterations in brain due to pathophysiological processes, but the effects of SCI treatment on brain have rarely been reported. Here, voxel-based morphometry is employed to investigate the effects of SCI and neurotrophin-3 (NT3) coupled chitosan-induced regeneration on brain and spinal cord structures in rhesus monkeys. Possible association between brain and spinal cord structural alterations is explored. The pain sensitivity and stepping ability of animals are collected to evaluate sensorimotor functional alterations. Compared with SCI, the unique effects of NT3 treatment on brain structure appear in extensive regions which involved in motor control and neuropathic pain, such as right visual cortex, superior parietal lobule, left superior frontal gyrus (SFG), middle frontal gyrus, inferior frontal gyrus, insula, secondary somatosensory cortex, anterior cingulate cortex, and bilateral caudate nucleus. Particularly, the structure of insula is significantly correlated with the pain sensitivity. Regenerative treatment also shows a protective effect on spinal cord structure. The associations between brain and spinal cord structural alterations are observed in right primary somatosensory cortex, SFG, and other regions. These results help further elucidate secondary effects on brain of SCI and provide a basis for evaluating the effects of NT3 treatment on brain structure. |
| first_indexed | 2024-12-23T06:05:36Z |
| format | Article |
| id | doaj.art-c8e839c238734dfa94f4b6088f5396be |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-23T06:05:36Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c8e839c238734dfa94f4b6088f5396be2022-12-21T17:57:35ZengNature PortfolioScientific Reports2045-23222022-04-0112111510.1038/s41598-022-09981-5NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortexShu-Sheng Bao0Can Zhao1Hao-Wei Chen2Ting Feng3Xiao-Jun Guo4Meng Xu5Jia-Sheng Rao6Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityInstitute of Rehabilitation Engineering, China Rehabilitation Science InstituteBeijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityBeijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityBeijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityDepartment of Orthopedics, The First Medical Center of PLA General HospitalBeijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityAbstract Spinal cord injury (SCI) may cause structural alterations in brain due to pathophysiological processes, but the effects of SCI treatment on brain have rarely been reported. Here, voxel-based morphometry is employed to investigate the effects of SCI and neurotrophin-3 (NT3) coupled chitosan-induced regeneration on brain and spinal cord structures in rhesus monkeys. Possible association between brain and spinal cord structural alterations is explored. The pain sensitivity and stepping ability of animals are collected to evaluate sensorimotor functional alterations. Compared with SCI, the unique effects of NT3 treatment on brain structure appear in extensive regions which involved in motor control and neuropathic pain, such as right visual cortex, superior parietal lobule, left superior frontal gyrus (SFG), middle frontal gyrus, inferior frontal gyrus, insula, secondary somatosensory cortex, anterior cingulate cortex, and bilateral caudate nucleus. Particularly, the structure of insula is significantly correlated with the pain sensitivity. Regenerative treatment also shows a protective effect on spinal cord structure. The associations between brain and spinal cord structural alterations are observed in right primary somatosensory cortex, SFG, and other regions. These results help further elucidate secondary effects on brain of SCI and provide a basis for evaluating the effects of NT3 treatment on brain structure.https://doi.org/10.1038/s41598-022-09981-5 |
| spellingShingle | Shu-Sheng Bao Can Zhao Hao-Wei Chen Ting Feng Xiao-Jun Guo Meng Xu Jia-Sheng Rao NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortex Scientific Reports |
| title | NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortex |
| title_full | NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortex |
| title_fullStr | NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortex |
| title_full_unstemmed | NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortex |
| title_short | NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortex |
| title_sort | nt3 treatment alters spinal cord injury induced changes in the gray matter volume of rhesus monkey cortex |
| url | https://doi.org/10.1038/s41598-022-09981-5 |
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