Advances on mechanisms of hypothalamic-pituitary-adrenal axis in abnormal glucose metabolism induced by air pollution
Recently, the adverse health effects of air pollution on human have attracted more and more attentions. Particulate matters (such as PM2.5 and PM10, with aerodynamic diameters ≤2.5 and ≤10 µm, respectively) and ozone are the major ambient pollutants in China. A large number of studies have shown tha...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Editorial Committee of Journal of Environmental and Occupational Medicine
2022-07-01
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| Series: | 环境与职业医学 |
| Subjects: | |
| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM21488 |
| _version_ | 1828288102424117248 |
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| author | Bin PAN Wenhui YANG Yanyi XU |
| author_facet | Bin PAN Wenhui YANG Yanyi XU |
| author_sort | Bin PAN |
| collection | DOAJ |
| description | Recently, the adverse health effects of air pollution on human have attracted more and more attentions. Particulate matters (such as PM2.5 and PM10, with aerodynamic diameters ≤2.5 and ≤10 µm, respectively) and ozone are the major ambient pollutants in China. A large number of studies have shown that exposure to particulate matters or ozone induces metabolic abnormalities, such as type 2 diabetes. However, the underlying biological mechanisms are not clear. In this review, we introduced the epidemiological and toxicological research progress of the effects of air pollutants on hypothalamus-pituitary-adrenal (HPA) axis. Considering the critical role of HPA axis in stress response, the molecular mechanisms of HPA axis-mediated glucose metabolism in fat, liver, muscle, and other tissues were also summarized. By integrating relevant literature and references, we proposed that HPA axis may play an important role in the abnormal glucose metabolism caused by air pollution, providing a scientific basis for future studies on the intervention methods of adverse health effects induced by air pollution. |
| first_indexed | 2024-04-13T09:58:53Z |
| format | Article |
| id | doaj.art-c8e8d497db79443fb0a724f093c5fd5d |
| institution | Directory Open Access Journal |
| issn | 2095-9982 |
| language | English |
| last_indexed | 2024-04-13T09:58:53Z |
| publishDate | 2022-07-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj.art-c8e8d497db79443fb0a724f093c5fd5d2022-12-22T02:51:17ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822022-07-0139782783210.11836/JEOM2148821488Advances on mechanisms of hypothalamic-pituitary-adrenal axis in abnormal glucose metabolism induced by air pollutionBin PAN0Wenhui YANG1Yanyi XU2NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai 200032, ChinaSchool of Public Health, Fudan University, Shanghai 200032, ChinaSchool of Public Health, Fudan University, Shanghai 200032, ChinaRecently, the adverse health effects of air pollution on human have attracted more and more attentions. Particulate matters (such as PM2.5 and PM10, with aerodynamic diameters ≤2.5 and ≤10 µm, respectively) and ozone are the major ambient pollutants in China. A large number of studies have shown that exposure to particulate matters or ozone induces metabolic abnormalities, such as type 2 diabetes. However, the underlying biological mechanisms are not clear. In this review, we introduced the epidemiological and toxicological research progress of the effects of air pollutants on hypothalamus-pituitary-adrenal (HPA) axis. Considering the critical role of HPA axis in stress response, the molecular mechanisms of HPA axis-mediated glucose metabolism in fat, liver, muscle, and other tissues were also summarized. By integrating relevant literature and references, we proposed that HPA axis may play an important role in the abnormal glucose metabolism caused by air pollution, providing a scientific basis for future studies on the intervention methods of adverse health effects induced by air pollution.http://www.jeom.org/article/cn/10.11836/JEOM21488air pollutionhypothalamic-pituitary-adrenal axisglucose metabolismmolecular mechanism |
| spellingShingle | Bin PAN Wenhui YANG Yanyi XU Advances on mechanisms of hypothalamic-pituitary-adrenal axis in abnormal glucose metabolism induced by air pollution 环境与职业医学 air pollution hypothalamic-pituitary-adrenal axis glucose metabolism molecular mechanism |
| title | Advances on mechanisms of hypothalamic-pituitary-adrenal axis in abnormal glucose metabolism induced by air pollution |
| title_full | Advances on mechanisms of hypothalamic-pituitary-adrenal axis in abnormal glucose metabolism induced by air pollution |
| title_fullStr | Advances on mechanisms of hypothalamic-pituitary-adrenal axis in abnormal glucose metabolism induced by air pollution |
| title_full_unstemmed | Advances on mechanisms of hypothalamic-pituitary-adrenal axis in abnormal glucose metabolism induced by air pollution |
| title_short | Advances on mechanisms of hypothalamic-pituitary-adrenal axis in abnormal glucose metabolism induced by air pollution |
| title_sort | advances on mechanisms of hypothalamic pituitary adrenal axis in abnormal glucose metabolism induced by air pollution |
| topic | air pollution hypothalamic-pituitary-adrenal axis glucose metabolism molecular mechanism |
| url | http://www.jeom.org/article/cn/10.11836/JEOM21488 |
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