Effect of Acetazolamide on Postural Control in Patients with COPD Travelling to 3100 m Randomized Trial
Patients with chronic obstructive pulmonary disease (COPD) may be susceptible to impairments in postural control (PC) when exposed to hypoxia at high altitude. This randomized, placebo-controlled, double-blind, parallel-design trial evaluated the effect of preventive acetazolamide treatment on PC in...
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| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1246 |
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| author | Aline Buergin Michael Furian Laura Mayer Mona Lichtblau Philipp M. Scheiwiller Ulan Sheraliev Talant M. Sooronbaev Silvia Ulrich Konrad E. Bloch |
| author_facet | Aline Buergin Michael Furian Laura Mayer Mona Lichtblau Philipp M. Scheiwiller Ulan Sheraliev Talant M. Sooronbaev Silvia Ulrich Konrad E. Bloch |
| author_sort | Aline Buergin |
| collection | DOAJ |
| description | Patients with chronic obstructive pulmonary disease (COPD) may be susceptible to impairments in postural control (PC) when exposed to hypoxia at high altitude. This randomized, placebo-controlled, double-blind, parallel-design trial evaluated the effect of preventive acetazolamide treatment on PC in lowlanders with COPD traveling to 3100 m. 127 lowlanders (85 men, 42 women) with moderate to severe COPD, aged 57 ± 8 y, living below 800 m, were randomized to treatment with acetazolamide 375 mg/d starting 24 h before ascent from 760 m to 3100 m and during a 2-day sojourn in a clinic at 3100 m. PC was evaluated at both altitudes with a balance platform on which patients were standing during five tests of 30 s each. The primary outcome was the center of pressure path length (COPL). In the placebo group, COPL significantly increased from (mean ± SD) 28.8 ± 9.7 cm at 760 m to 30.0 ± 10.0 cm at 3100 m (<i>p</i> = 0.002). In the acetazolamide group, COPL at 760 m and 3100 m were similar with 27.6 ± 9.6 cm and 28.4 ± 9.7 cm (<i>p</i> = 0.069). The mean between-groups difference (acetazolamide-placebo) in altitude-induced change of COPL was −0.54 cm (95%CI −1.66 to 0.58, <i>p</i> = 0.289). Multivariable regression analysis confirmed an increase in COPL of 0.98 cm (0.39 to 1.58, <i>p</i> = 0.001) with ascent from 760 to 3100 m, but no significant effect of acetazolamide (0.66 cm, 95%CI −0.25 to 1.57, <i>p</i> = 0.156) when adjusting for several confounders. In lowlanders with moderate to severe COPD, an ascent to high altitude was associated with impaired postural control and this was not prevented by acetazolamide. |
| first_indexed | 2024-03-11T08:39:03Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:39:03Z |
| publishDate | 2023-02-01 |
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| spelling | doaj.art-c8e8eaec40af47c985f32dcad131f56d2023-11-16T21:16:53ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124124610.3390/jcm12041246Effect of Acetazolamide on Postural Control in Patients with COPD Travelling to 3100 m Randomized TrialAline Buergin0Michael Furian1Laura Mayer2Mona Lichtblau3Philipp M. Scheiwiller4Ulan Sheraliev5Talant M. Sooronbaev6Silvia Ulrich7Konrad E. Bloch8Department of Respiratory Medicine, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandDepartment of Respiratory Medicine, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandDepartment of Respiratory Medicine, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandDepartment of Respiratory Medicine, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandDepartment of Respiratory Medicine, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandSwiss-Kyrgyz High Altitude Medicine and Research Initiative, 8091 Zurich, SwitzerlandSwiss-Kyrgyz High Altitude Medicine and Research Initiative, 8091 Zurich, SwitzerlandDepartment of Respiratory Medicine, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandDepartment of Respiratory Medicine, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandPatients with chronic obstructive pulmonary disease (COPD) may be susceptible to impairments in postural control (PC) when exposed to hypoxia at high altitude. This randomized, placebo-controlled, double-blind, parallel-design trial evaluated the effect of preventive acetazolamide treatment on PC in lowlanders with COPD traveling to 3100 m. 127 lowlanders (85 men, 42 women) with moderate to severe COPD, aged 57 ± 8 y, living below 800 m, were randomized to treatment with acetazolamide 375 mg/d starting 24 h before ascent from 760 m to 3100 m and during a 2-day sojourn in a clinic at 3100 m. PC was evaluated at both altitudes with a balance platform on which patients were standing during five tests of 30 s each. The primary outcome was the center of pressure path length (COPL). In the placebo group, COPL significantly increased from (mean ± SD) 28.8 ± 9.7 cm at 760 m to 30.0 ± 10.0 cm at 3100 m (<i>p</i> = 0.002). In the acetazolamide group, COPL at 760 m and 3100 m were similar with 27.6 ± 9.6 cm and 28.4 ± 9.7 cm (<i>p</i> = 0.069). The mean between-groups difference (acetazolamide-placebo) in altitude-induced change of COPL was −0.54 cm (95%CI −1.66 to 0.58, <i>p</i> = 0.289). Multivariable regression analysis confirmed an increase in COPL of 0.98 cm (0.39 to 1.58, <i>p</i> = 0.001) with ascent from 760 to 3100 m, but no significant effect of acetazolamide (0.66 cm, 95%CI −0.25 to 1.57, <i>p</i> = 0.156) when adjusting for several confounders. In lowlanders with moderate to severe COPD, an ascent to high altitude was associated with impaired postural control and this was not prevented by acetazolamide.https://www.mdpi.com/2077-0383/12/4/1246postural controlhigh-altitudeCOPDacetazolamidehypoxiahypoxemia |
| spellingShingle | Aline Buergin Michael Furian Laura Mayer Mona Lichtblau Philipp M. Scheiwiller Ulan Sheraliev Talant M. Sooronbaev Silvia Ulrich Konrad E. Bloch Effect of Acetazolamide on Postural Control in Patients with COPD Travelling to 3100 m Randomized Trial Journal of Clinical Medicine postural control high-altitude COPD acetazolamide hypoxia hypoxemia |
| title | Effect of Acetazolamide on Postural Control in Patients with COPD Travelling to 3100 m Randomized Trial |
| title_full | Effect of Acetazolamide on Postural Control in Patients with COPD Travelling to 3100 m Randomized Trial |
| title_fullStr | Effect of Acetazolamide on Postural Control in Patients with COPD Travelling to 3100 m Randomized Trial |
| title_full_unstemmed | Effect of Acetazolamide on Postural Control in Patients with COPD Travelling to 3100 m Randomized Trial |
| title_short | Effect of Acetazolamide on Postural Control in Patients with COPD Travelling to 3100 m Randomized Trial |
| title_sort | effect of acetazolamide on postural control in patients with copd travelling to 3100 m randomized trial |
| topic | postural control high-altitude COPD acetazolamide hypoxia hypoxemia |
| url | https://www.mdpi.com/2077-0383/12/4/1246 |
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