Theoretical investigation on a simple turn on fluorescent probe for detection of biothiols based on coumarin unit
The discovery of a simple and efficient detection method for biothiols would be scientifically significant due to the crucial role of them in various physiological processes. Recently, a simple fluorescent probe, DEMCA-NBSC, based on coumarin fragments, was developed by Ding et al., and provided an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1290745/full |
| _version_ | 1797632948956037120 |
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| author | Tianhao Ma He Huang Yuling Liu Yongjin Peng |
| author_facet | Tianhao Ma He Huang Yuling Liu Yongjin Peng |
| author_sort | Tianhao Ma |
| collection | DOAJ |
| description | The discovery of a simple and efficient detection method for biothiols would be scientifically significant due to the crucial role of them in various physiological processes. Recently, a simple fluorescent probe, DEMCA-NBSC, based on coumarin fragments, was developed by Ding et al., and provided an efficient way for real-time sensing of biothiols both in vivo and vitro. Theoretical insights to the fluorescence sensing mechanism of the probe were provided in this work. Details of the electron transfer process in the probe under optical excitation and the fluorescent character of the probe were analyzed using a quantum mechanical method. All these theoretical results could inspire the development of a highly convenient and efficient fluorescent probe to sense biothiols both in vivo and vitro. |
| first_indexed | 2024-03-11T11:44:57Z |
| format | Article |
| id | doaj.art-c8eadccec980438c9be612f54ff7c06b |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-03-11T11:44:57Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-c8eadccec980438c9be612f54ff7c06b2023-11-09T16:18:01ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462023-11-011110.3389/fchem.2023.12907451290745Theoretical investigation on a simple turn on fluorescent probe for detection of biothiols based on coumarin unitTianhao Ma0He Huang1Yuling Liu2Yongjin Peng3Affiliated 3rd Hospital, Jinzhou Medical University, Jinzhou, ChinaCollege of Bio-Informational Engineering, Jinzhou Medical University, Jinzhou, ChinaCollege of Bio-Informational Engineering, Jinzhou Medical University, Jinzhou, ChinaCollege of Bio-Informational Engineering, Jinzhou Medical University, Jinzhou, ChinaThe discovery of a simple and efficient detection method for biothiols would be scientifically significant due to the crucial role of them in various physiological processes. Recently, a simple fluorescent probe, DEMCA-NBSC, based on coumarin fragments, was developed by Ding et al., and provided an efficient way for real-time sensing of biothiols both in vivo and vitro. Theoretical insights to the fluorescence sensing mechanism of the probe were provided in this work. Details of the electron transfer process in the probe under optical excitation and the fluorescent character of the probe were analyzed using a quantum mechanical method. All these theoretical results could inspire the development of a highly convenient and efficient fluorescent probe to sense biothiols both in vivo and vitro.https://www.frontiersin.org/articles/10.3389/fchem.2023.1290745/fullfluorescent probebiothiolsquantum mechanicalelectron transferproton transfer |
| spellingShingle | Tianhao Ma He Huang Yuling Liu Yongjin Peng Theoretical investigation on a simple turn on fluorescent probe for detection of biothiols based on coumarin unit Frontiers in Chemistry fluorescent probe biothiols quantum mechanical electron transfer proton transfer |
| title | Theoretical investigation on a simple turn on fluorescent probe for detection of biothiols based on coumarin unit |
| title_full | Theoretical investigation on a simple turn on fluorescent probe for detection of biothiols based on coumarin unit |
| title_fullStr | Theoretical investigation on a simple turn on fluorescent probe for detection of biothiols based on coumarin unit |
| title_full_unstemmed | Theoretical investigation on a simple turn on fluorescent probe for detection of biothiols based on coumarin unit |
| title_short | Theoretical investigation on a simple turn on fluorescent probe for detection of biothiols based on coumarin unit |
| title_sort | theoretical investigation on a simple turn on fluorescent probe for detection of biothiols based on coumarin unit |
| topic | fluorescent probe biothiols quantum mechanical electron transfer proton transfer |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2023.1290745/full |
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