circRNAs: Insight Into Their Role in Tumor-Associated Macrophages
Currently, it is well known that the tumor microenvironment not only provides energy support for tumor growth but also regulates tumor signaling pathways and promotes the proliferation, invasion, metastasis, and drug resistance of tumor cells. The tumor microenvironment, especially the function and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.780744/full |
| _version_ | 1818432703946555392 |
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| author | Saili Duan Saili Duan Saili Duan Saili Duan Shan Wang Shan Wang Shan Wang Shan Wang Tao Huang Tao Huang Tao Huang Tao Huang Junpu Wang Junpu Wang Junpu Wang Junpu Wang Xiaoqing Yuan Xiaoqing Yuan |
| author_facet | Saili Duan Saili Duan Saili Duan Saili Duan Shan Wang Shan Wang Shan Wang Shan Wang Tao Huang Tao Huang Tao Huang Tao Huang Junpu Wang Junpu Wang Junpu Wang Junpu Wang Xiaoqing Yuan Xiaoqing Yuan |
| author_sort | Saili Duan |
| collection | DOAJ |
| description | Currently, it is well known that the tumor microenvironment not only provides energy support for tumor growth but also regulates tumor signaling pathways and promotes the proliferation, invasion, metastasis, and drug resistance of tumor cells. The tumor microenvironment, especially the function and mechanism of tumor-associated macrophages (TAMs), has attracted great attention. TAMs are the most common immune cells in the tumor microenvironment and play a vital role in the occurrence and development of tumors. circular RNA (circRNA) is a unique, widespread, and stable form of non-coding RNA (ncRNA), but little is known about the role of circRNAs in TAMs or how TAMs affect circRNAs. In this review, we summarize the specific manifestations of circRNAs that affect the tumor-associated macrophages and play a significant role in tumor progression. This review helps improve our understanding of the association between circRNAs and TAMs, thereby promoting the development and progress of potential clinical targeted therapies. |
| first_indexed | 2024-12-14T16:09:25Z |
| format | Article |
| id | doaj.art-c8ed8bd9cf374629803124f15e83f6ad |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T16:09:25Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c8ed8bd9cf374629803124f15e83f6ad2022-12-21T22:55:02ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-12-011110.3389/fonc.2021.780744780744circRNAs: Insight Into Their Role in Tumor-Associated MacrophagesSaili Duan0Saili Duan1Saili Duan2Saili Duan3Shan Wang4Shan Wang5Shan Wang6Shan Wang7Tao Huang8Tao Huang9Tao Huang10Tao Huang11Junpu Wang12Junpu Wang13Junpu Wang14Junpu Wang15Xiaoqing Yuan16Xiaoqing Yuan17Department of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaXiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Pathology, School of Basic Medicine, Central South University, Changsha City, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaXiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Pathology, School of Basic Medicine, Central South University, Changsha City, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaXiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Pathology, School of Basic Medicine, Central South University, Changsha City, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaXiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Pathology, School of Basic Medicine, Central South University, Changsha City, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaBreast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaCurrently, it is well known that the tumor microenvironment not only provides energy support for tumor growth but also regulates tumor signaling pathways and promotes the proliferation, invasion, metastasis, and drug resistance of tumor cells. The tumor microenvironment, especially the function and mechanism of tumor-associated macrophages (TAMs), has attracted great attention. TAMs are the most common immune cells in the tumor microenvironment and play a vital role in the occurrence and development of tumors. circular RNA (circRNA) is a unique, widespread, and stable form of non-coding RNA (ncRNA), but little is known about the role of circRNAs in TAMs or how TAMs affect circRNAs. In this review, we summarize the specific manifestations of circRNAs that affect the tumor-associated macrophages and play a significant role in tumor progression. This review helps improve our understanding of the association between circRNAs and TAMs, thereby promoting the development and progress of potential clinical targeted therapies.https://www.frontiersin.org/articles/10.3389/fonc.2021.780744/fullcircRNATAMsM2 macrophagepolarizationcancer |
| spellingShingle | Saili Duan Saili Duan Saili Duan Saili Duan Shan Wang Shan Wang Shan Wang Shan Wang Tao Huang Tao Huang Tao Huang Tao Huang Junpu Wang Junpu Wang Junpu Wang Junpu Wang Xiaoqing Yuan Xiaoqing Yuan circRNAs: Insight Into Their Role in Tumor-Associated Macrophages Frontiers in Oncology circRNA TAMs M2 macrophage polarization cancer |
| title | circRNAs: Insight Into Their Role in Tumor-Associated Macrophages |
| title_full | circRNAs: Insight Into Their Role in Tumor-Associated Macrophages |
| title_fullStr | circRNAs: Insight Into Their Role in Tumor-Associated Macrophages |
| title_full_unstemmed | circRNAs: Insight Into Their Role in Tumor-Associated Macrophages |
| title_short | circRNAs: Insight Into Their Role in Tumor-Associated Macrophages |
| title_sort | circrnas insight into their role in tumor associated macrophages |
| topic | circRNA TAMs M2 macrophage polarization cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.780744/full |
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