Relationship Between Disease Activity, Levels of IFN-a, IL-4, IL-6, and Anti-NMDA to Cognitive Dysfunction (MoCA-INA Score) in Systemic Lupus Erythematosus (SLE) Patients with Cognitive Dysfunction
Background: Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) is a condition that impacts the patients’ brain with SLE, and cognitive dysfunction (CD) is the most common manifestation. Subsequently, the CD hurts the life quality of SLE patients and creates impaired social function. Furthermore,...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2023-07-01
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| Series: | Acta Medica Indonesiana |
| Subjects: | |
| Online Access: | https://actamedindones.org/index.php/ijim/article/view/2475 |
| _version_ | 1797642328101355520 |
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| author | Bantar Suntoko Suharyo Hadisaputro Handono Kalim Suyanto Hadi Wahyu Adirama Saputra |
| author_facet | Bantar Suntoko Suharyo Hadisaputro Handono Kalim Suyanto Hadi Wahyu Adirama Saputra |
| author_sort | Bantar Suntoko |
| collection | DOAJ |
| description | Background: Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) is a condition that impacts the patients’ brain with SLE, and cognitive dysfunction (CD) is the most common manifestation. Subsequently, the CD hurts the life quality of SLE patients and creates impaired social function. Furthermore, the Montreal Cognitive Assessment (MoCA-INA) is a screening instrument to evaluate cognitive function. In the context of lupus, cytokines, and autoantibodies act as biomarkers in SLE disease control activities. Purpose: The aim of this study was to analyze the correlation between disease activity, IFN-a, IL-4, IL-6 and Anti-NMDA on CD (MoCA-INA Score) in SLE patients with CD. Methods: This analytical observational study was performed with a cross-sectional design and included a sample of 56 SLE patients. The independent variables were the degree of the disease activity, and levels of IFN-a, IL-4, IL-6, and anti-NMDA. The dependent variable consisted of the degree of CD (MoCA-INA score), while the confounding variables were age, DM, gender, hypertension, obesity, and dyslipidemia. Subsequently, the CD was described as a MoCA-INA score <26, and disease activity was estimated based on the SLEDAI score. Results: Increased IL-6 levels were correlated with decreased MoCA-INA scores (p=0.003; r= -0.387). Younger age was found to be associated with more severe CD (p=0.006) Conclusion:In conclusion, IL-6 levels can be used as a predictor severity of CD in SLE patients. |
| first_indexed | 2024-03-11T13:58:28Z |
| format | Article |
| id | doaj.art-c8f44afa807b4d83a054685a83d985da |
| institution | Directory Open Access Journal |
| issn | 0125-9326 2338-2732 |
| language | English |
| last_indexed | 2024-03-11T13:58:28Z |
| publishDate | 2023-07-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj.art-c8f44afa807b4d83a054685a83d985da2023-11-02T05:29:02ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322023-07-01553606Relationship Between Disease Activity, Levels of IFN-a, IL-4, IL-6, and Anti-NMDA to Cognitive Dysfunction (MoCA-INA Score) in Systemic Lupus Erythematosus (SLE) Patients with Cognitive DysfunctionBantar Suntoko0Suharyo Hadisaputro1Handono Kalim2Suyanto Hadi3Wahyu Adirama Saputra4Doctoral study Program of Medical and Health Science, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaDivision of Tropical Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Diponegoro University - Kariadi Hospital, Semarang, IndonesiaDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Brawijaya University - Saiful Anwar Hospital, Malang, IndonesiaDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University - Kariadi Hospital, Semarang, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Diponegoro University - Kariadi Hospital, Semarang, IndonesiaBackground: Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) is a condition that impacts the patients’ brain with SLE, and cognitive dysfunction (CD) is the most common manifestation. Subsequently, the CD hurts the life quality of SLE patients and creates impaired social function. Furthermore, the Montreal Cognitive Assessment (MoCA-INA) is a screening instrument to evaluate cognitive function. In the context of lupus, cytokines, and autoantibodies act as biomarkers in SLE disease control activities. Purpose: The aim of this study was to analyze the correlation between disease activity, IFN-a, IL-4, IL-6 and Anti-NMDA on CD (MoCA-INA Score) in SLE patients with CD. Methods: This analytical observational study was performed with a cross-sectional design and included a sample of 56 SLE patients. The independent variables were the degree of the disease activity, and levels of IFN-a, IL-4, IL-6, and anti-NMDA. The dependent variable consisted of the degree of CD (MoCA-INA score), while the confounding variables were age, DM, gender, hypertension, obesity, and dyslipidemia. Subsequently, the CD was described as a MoCA-INA score <26, and disease activity was estimated based on the SLEDAI score. Results: Increased IL-6 levels were correlated with decreased MoCA-INA scores (p=0.003; r= -0.387). Younger age was found to be associated with more severe CD (p=0.006) Conclusion:In conclusion, IL-6 levels can be used as a predictor severity of CD in SLE patients.https://actamedindones.org/index.php/ijim/article/view/2475cognitive dysfunctionsystemic lupus erythematosusdisease activityifn-ail-4il-6anti-nmda |
| spellingShingle | Bantar Suntoko Suharyo Hadisaputro Handono Kalim Suyanto Hadi Wahyu Adirama Saputra Relationship Between Disease Activity, Levels of IFN-a, IL-4, IL-6, and Anti-NMDA to Cognitive Dysfunction (MoCA-INA Score) in Systemic Lupus Erythematosus (SLE) Patients with Cognitive Dysfunction Acta Medica Indonesiana cognitive dysfunction systemic lupus erythematosus disease activity ifn-a il-4 il-6 anti-nmda |
| title | Relationship Between Disease Activity, Levels of IFN-a, IL-4, IL-6, and Anti-NMDA to Cognitive Dysfunction (MoCA-INA Score) in Systemic Lupus Erythematosus (SLE) Patients with Cognitive Dysfunction |
| title_full | Relationship Between Disease Activity, Levels of IFN-a, IL-4, IL-6, and Anti-NMDA to Cognitive Dysfunction (MoCA-INA Score) in Systemic Lupus Erythematosus (SLE) Patients with Cognitive Dysfunction |
| title_fullStr | Relationship Between Disease Activity, Levels of IFN-a, IL-4, IL-6, and Anti-NMDA to Cognitive Dysfunction (MoCA-INA Score) in Systemic Lupus Erythematosus (SLE) Patients with Cognitive Dysfunction |
| title_full_unstemmed | Relationship Between Disease Activity, Levels of IFN-a, IL-4, IL-6, and Anti-NMDA to Cognitive Dysfunction (MoCA-INA Score) in Systemic Lupus Erythematosus (SLE) Patients with Cognitive Dysfunction |
| title_short | Relationship Between Disease Activity, Levels of IFN-a, IL-4, IL-6, and Anti-NMDA to Cognitive Dysfunction (MoCA-INA Score) in Systemic Lupus Erythematosus (SLE) Patients with Cognitive Dysfunction |
| title_sort | relationship between disease activity levels of ifn a il 4 il 6 and anti nmda to cognitive dysfunction moca ina score in systemic lupus erythematosus sle patients with cognitive dysfunction |
| topic | cognitive dysfunction systemic lupus erythematosus disease activity ifn-a il-4 il-6 anti-nmda |
| url | https://actamedindones.org/index.php/ijim/article/view/2475 |
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