BIND&MODIFY: a long-range method for single-molecule mapping of chromatin modifications in eukaryotes

BIND&MODIFY: a long-range method for single-molecule mapping of chromatin modifications in eukaryotes

Abstract Epigenetic modifications of histones are associated with development and pathogenesis of disease. Existing approaches cannot provide insights into long-range interactions and represent the average chromatin state. Here we describe BIND&MODIFY, a method using long-read sequencing for pro...

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Détails bibliographiques
Auteurs principaux: Zhe Weng, Fengying Ruan, Weitian Chen, Zhichao Chen, Yeming Xie, Meng Luo, Zhe Xie, Chen Zhang, Juan Wang, Yuxin Sun, Yitong Fang, Mei Guo, Chen Tan, Wenfang Chen, Yiqin Tong, Yaning Li, Hongqi Wang, Chong Tang
Format: Article
Langue:English
Publié: BMC 2023-03-01
Collection:Genome Biology
Sujets:
Epigenetics
Histone modification
CpG methylation
H3K27me3
CTCF
m6A
Accès en ligne:https://doi.org/10.1186/s13059-023-02896-y

Internet

https://doi.org/10.1186/s13059-023-02896-y

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