Border zones of evidence: How non-evidence based factors influence evidence generation and clinical practice in stroke medicine
The interpretation of the results of clinical trials should be done by examining the finer prints of extraneous factors such as stopping rules, interim analysis, intricacies of patient selection, and the rationale of decisions that lead to non-prespecified termination. This can be done only by criti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=3;spage=249;epage=252;aulast=Srijithesh |
| _version_ | 1818514960957833216 |
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| author | P R Srijithesh Shakir Husain |
| author_facet | P R Srijithesh Shakir Husain |
| author_sort | P R Srijithesh |
| collection | DOAJ |
| description | The interpretation of the results of clinical trials should be done by examining the finer prints of extraneous factors such as stopping rules, interim analysis, intricacies of patient selection, and the rationale of decisions that lead to non-prespecified termination. This can be done only by critical education in the art and science of interpretation of evidence emerging from clinical trials. The pioneering pivotal studies, namely, NINDS rtPA and ECASS III trials, hold disproportionate influence in determining the contours of the subsequent fate of clinical trials and treatment guidelines. It needs to be recognized that the pooling of studies using dissimilar trial designs, notwithstanding similar patient profiles, would undermine the positive signal emerging from the studies that have used better selection methodologies to homogenize the study population. |
| first_indexed | 2024-12-11T00:22:47Z |
| format | Article |
| id | doaj.art-c8f85829ea44465baf64334e760acf71 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-11T00:22:47Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-c8f85829ea44465baf64334e760acf712022-12-22T01:27:41ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492020-01-0123324925210.4103/aian.AIAN_15_20Border zones of evidence: How non-evidence based factors influence evidence generation and clinical practice in stroke medicineP R SrijitheshShakir HusainThe interpretation of the results of clinical trials should be done by examining the finer prints of extraneous factors such as stopping rules, interim analysis, intricacies of patient selection, and the rationale of decisions that lead to non-prespecified termination. This can be done only by critical education in the art and science of interpretation of evidence emerging from clinical trials. The pioneering pivotal studies, namely, NINDS rtPA and ECASS III trials, hold disproportionate influence in determining the contours of the subsequent fate of clinical trials and treatment guidelines. It needs to be recognized that the pooling of studies using dissimilar trial designs, notwithstanding similar patient profiles, would undermine the positive signal emerging from the studies that have used better selection methodologies to homogenize the study population.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=3;spage=249;epage=252;aulast=Srijitheshacute stroke trialsborder zones of evidencestroke medicine |
| spellingShingle | P R Srijithesh Shakir Husain Border zones of evidence: How non-evidence based factors influence evidence generation and clinical practice in stroke medicine Annals of Indian Academy of Neurology acute stroke trials border zones of evidence stroke medicine |
| title | Border zones of evidence: How non-evidence based factors influence evidence generation and clinical practice in stroke medicine |
| title_full | Border zones of evidence: How non-evidence based factors influence evidence generation and clinical practice in stroke medicine |
| title_fullStr | Border zones of evidence: How non-evidence based factors influence evidence generation and clinical practice in stroke medicine |
| title_full_unstemmed | Border zones of evidence: How non-evidence based factors influence evidence generation and clinical practice in stroke medicine |
| title_short | Border zones of evidence: How non-evidence based factors influence evidence generation and clinical practice in stroke medicine |
| title_sort | border zones of evidence how non evidence based factors influence evidence generation and clinical practice in stroke medicine |
| topic | acute stroke trials border zones of evidence stroke medicine |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=3;spage=249;epage=252;aulast=Srijithesh |
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