A pilot study: Nano‐hydroxyapatite‐PEG/PLA containing low dose rhBMP2 stimulates proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells

A pilot study: Nano‐hydroxyapatite‐PEG/PLA containing low dose rhBMP2 stimulates proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells

Abstract Background Bone morphogenetic protein 2 (BMP2) can enhance posterolateral spinal fusion (PLSF). The minimum effective dose that may stimulate mesenchymal stem cells however remains unknown. Nano‐hydroxyapatite (nHAp) polyethylene glycol (PEG)/polylactic acid (PLA) was combined with recombin...

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Bibliographic Details
Main Authors: Eda Çiftci Dede, Merve Gizer, Feza Korkusuz, Zeynep Bal, Hiroyuki Ishiguro, Hideki Yoshikawa, Takashi Kaito, Petek Korkusuz
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:JOR Spine
Subjects:
bone regeneration
mesenchymal stem cells
nano‐hydroxyapatite
polyethylene glycol
polylactic acid
posterolateral spinal fusion
Online Access:https://doi.org/10.1002/jsp2.1258

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