Correlation between gene mutation status and clinicopathologic features in early multiple primary lung cancer
ObjectiveTo understand the characteristics of genetic mutation in multiple primary lung cancer so as to guide clinical decisions in targeted therapy.MethodsWe analyzed a total of 265 tumors from 111 patients who underwent surgery for multiple lung cancers. Individual tumors were subjected to histolo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1110259/full |
| _version_ | 1827968640676265984 |
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| author | Fei Teng Jian Xu Jian Wang Bo Yang Yong-Zhong Wu Yue-Quan Jiang Zhi-Qiang Wang |
| author_facet | Fei Teng Jian Xu Jian Wang Bo Yang Yong-Zhong Wu Yue-Quan Jiang Zhi-Qiang Wang |
| author_sort | Fei Teng |
| collection | DOAJ |
| description | ObjectiveTo understand the characteristics of genetic mutation in multiple primary lung cancer so as to guide clinical decisions in targeted therapy.MethodsWe analyzed a total of 265 tumors from 111 patients who underwent surgery for multiple lung cancers. Individual tumors were subjected to histological evaluation and gene mutation analysis using ABI 7500 Fluorescence quantitative PCR.ResultsIn this study, we analyzed demographic and clinical parameters such as age, gender, smoking, alcohol consumption, pathological type, number of nodules, and other details of 111 patients with early multiple primary lung cancer. We also compared the clinicopathologic characteristics of different populations based on the gene mutation status of pulmonary nodules. Subsequently, we performed a clinicopathological analysis of all 265 pulmonary nodules from these patients. Results showed significant differences in clinicopathological features of pulmonary nodules in different genetic mutations.ConclusionThis study revealed the gene mutation characteristics and clinicopathological features in early multiple primary lung cancer. We found that the gene mutation status between different nodules in patients with early multiple primary lung cancer was inconsistent in most cases. Therefore, the use of targeted therapy based on the genetic sequencing of only one nodule, is unreliable. We hope this study can be helpful in guiding clinical treatment decisions. |
| first_indexed | 2024-04-09T18:24:42Z |
| format | Article |
| id | doaj.art-c8fbb72bf7214976a2475f33630c6045 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T18:24:42Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c8fbb72bf7214976a2475f33630c60452023-04-12T04:27:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-04-011310.3389/fonc.2023.11102591110259Correlation between gene mutation status and clinicopathologic features in early multiple primary lung cancerFei Teng0Jian Xu1Jian Wang2Bo Yang3Yong-Zhong Wu4Yue-Quan Jiang5Zhi-Qiang Wang6Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, ChinaKey Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, ChinaDepartment of Neurovascular Surgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, Changchun, ChinaKey Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, ChinaKey Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, ChinaKey Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, ChinaObjectiveTo understand the characteristics of genetic mutation in multiple primary lung cancer so as to guide clinical decisions in targeted therapy.MethodsWe analyzed a total of 265 tumors from 111 patients who underwent surgery for multiple lung cancers. Individual tumors were subjected to histological evaluation and gene mutation analysis using ABI 7500 Fluorescence quantitative PCR.ResultsIn this study, we analyzed demographic and clinical parameters such as age, gender, smoking, alcohol consumption, pathological type, number of nodules, and other details of 111 patients with early multiple primary lung cancer. We also compared the clinicopathologic characteristics of different populations based on the gene mutation status of pulmonary nodules. Subsequently, we performed a clinicopathological analysis of all 265 pulmonary nodules from these patients. Results showed significant differences in clinicopathological features of pulmonary nodules in different genetic mutations.ConclusionThis study revealed the gene mutation characteristics and clinicopathological features in early multiple primary lung cancer. We found that the gene mutation status between different nodules in patients with early multiple primary lung cancer was inconsistent in most cases. Therefore, the use of targeted therapy based on the genetic sequencing of only one nodule, is unreliable. We hope this study can be helpful in guiding clinical treatment decisions.https://www.frontiersin.org/articles/10.3389/fonc.2023.1110259/fullclinicopathological featuresdemographic characteristicsgene mutationground-glass nodulemultiple primary lung cancer |
| spellingShingle | Fei Teng Jian Xu Jian Wang Bo Yang Yong-Zhong Wu Yue-Quan Jiang Zhi-Qiang Wang Correlation between gene mutation status and clinicopathologic features in early multiple primary lung cancer Frontiers in Oncology clinicopathological features demographic characteristics gene mutation ground-glass nodule multiple primary lung cancer |
| title | Correlation between gene mutation status and clinicopathologic features in early multiple primary lung cancer |
| title_full | Correlation between gene mutation status and clinicopathologic features in early multiple primary lung cancer |
| title_fullStr | Correlation between gene mutation status and clinicopathologic features in early multiple primary lung cancer |
| title_full_unstemmed | Correlation between gene mutation status and clinicopathologic features in early multiple primary lung cancer |
| title_short | Correlation between gene mutation status and clinicopathologic features in early multiple primary lung cancer |
| title_sort | correlation between gene mutation status and clinicopathologic features in early multiple primary lung cancer |
| topic | clinicopathological features demographic characteristics gene mutation ground-glass nodule multiple primary lung cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1110259/full |
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