Vaccine‐Associated Leptospira Antibodies in Client‐Owned Dogs
Background Long‐term microscopic agglutination test (MAT) results after vaccination with 4‐serovar Leptospira vaccines are not available for all vaccines used in client‐owned dogs. Hypothesis/Objectives To determine antibody responses of client‐owned dogs given 1 of 4 commercially available Leptospi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-05-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.12337 |
| _version_ | 1828204703541886976 |
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| author | L.E.R. Martin K.T. Wiggans S.A. Jablonski Wennogle K. Curtis R. Chandrashekar M.R. Lappin |
| author_facet | L.E.R. Martin K.T. Wiggans S.A. Jablonski Wennogle K. Curtis R. Chandrashekar M.R. Lappin |
| author_sort | L.E.R. Martin |
| collection | DOAJ |
| description | Background Long‐term microscopic agglutination test (MAT) results after vaccination with 4‐serovar Leptospira vaccines are not available for all vaccines used in client‐owned dogs. Hypothesis/Objectives To determine antibody responses of client‐owned dogs given 1 of 4 commercially available Leptospira vaccines. Animals Healthy client‐owned dogs (n = 32) with no history of Leptospira vaccination for at least the previous year. Methods Dogs were given 1 of 4 Leptospira vaccines on week 0 and then approximately on week 3 and week 52. Sera were collected before vaccine administration on week 0 and then within 3 days of week 3, within 2 days of week 4, and approximately on weeks 7, 15, 29, 52, and 56. Antibody titers against Leptospira serovars bratislava, canicola, grippotyphosa, hardjo, icterohemorrhagiae, and pomona and were determined by MAT. Results When compared among vaccines, MAT results varied in maximal titers, the serovars inducing maximal titers, and the time required to reach maximal titers. Each vaccine induced at least some MAT titers ≥1 : 800. Most dogs were negative for antibodies against all serovars 1 year after vaccination, and anamnestic responses were variable. Conclusions and Clinical Importance Dogs vaccinated with Leptospira vaccines have variable MAT titers over time, and antibodies should not be used to predict resistance to Leptospira infection. MAT titers ≥1 : 800 can develop after Leptospira spp. vaccination, which can complicate the clinical diagnosis of leptospirosis. |
| first_indexed | 2024-04-12T12:28:03Z |
| format | Article |
| id | doaj.art-c8fde654773743698e2029c68ce65c19 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-12T12:28:03Z |
| publishDate | 2014-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-c8fde654773743698e2029c68ce65c192022-12-22T03:33:07ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762014-05-0128378979210.1111/jvim.12337Vaccine‐Associated Leptospira Antibodies in Client‐Owned DogsL.E.R. Martin0K.T. Wiggans1S.A. Jablonski Wennogle2K. Curtis3R. Chandrashekar4M.R. Lappin5Department of Clinical Sciences Colorado State University Fort Collins CODepartment of Clinical Sciences Colorado State University Fort Collins CODepartment of Clinical Sciences Colorado State University Fort Collins COIDEXX Laboratories, Inc Westbrook MEIDEXX Laboratories, Inc Westbrook MEDepartment of Clinical Sciences Colorado State University Fort Collins COBackground Long‐term microscopic agglutination test (MAT) results after vaccination with 4‐serovar Leptospira vaccines are not available for all vaccines used in client‐owned dogs. Hypothesis/Objectives To determine antibody responses of client‐owned dogs given 1 of 4 commercially available Leptospira vaccines. Animals Healthy client‐owned dogs (n = 32) with no history of Leptospira vaccination for at least the previous year. Methods Dogs were given 1 of 4 Leptospira vaccines on week 0 and then approximately on week 3 and week 52. Sera were collected before vaccine administration on week 0 and then within 3 days of week 3, within 2 days of week 4, and approximately on weeks 7, 15, 29, 52, and 56. Antibody titers against Leptospira serovars bratislava, canicola, grippotyphosa, hardjo, icterohemorrhagiae, and pomona and were determined by MAT. Results When compared among vaccines, MAT results varied in maximal titers, the serovars inducing maximal titers, and the time required to reach maximal titers. Each vaccine induced at least some MAT titers ≥1 : 800. Most dogs were negative for antibodies against all serovars 1 year after vaccination, and anamnestic responses were variable. Conclusions and Clinical Importance Dogs vaccinated with Leptospira vaccines have variable MAT titers over time, and antibodies should not be used to predict resistance to Leptospira infection. MAT titers ≥1 : 800 can develop after Leptospira spp. vaccination, which can complicate the clinical diagnosis of leptospirosis.https://doi.org/10.1111/jvim.12337SerologyTiters |
| spellingShingle | L.E.R. Martin K.T. Wiggans S.A. Jablonski Wennogle K. Curtis R. Chandrashekar M.R. Lappin Vaccine‐Associated Leptospira Antibodies in Client‐Owned Dogs Journal of Veterinary Internal Medicine Serology Titers |
| title | Vaccine‐Associated Leptospira Antibodies in Client‐Owned Dogs |
| title_full | Vaccine‐Associated Leptospira Antibodies in Client‐Owned Dogs |
| title_fullStr | Vaccine‐Associated Leptospira Antibodies in Client‐Owned Dogs |
| title_full_unstemmed | Vaccine‐Associated Leptospira Antibodies in Client‐Owned Dogs |
| title_short | Vaccine‐Associated Leptospira Antibodies in Client‐Owned Dogs |
| title_sort | vaccine associated leptospira antibodies in client owned dogs |
| topic | Serology Titers |
| url | https://doi.org/10.1111/jvim.12337 |
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