Pulmonary function and trajectories of cognitive decline in aging population
Background: The number of older people with cognitive impairment is increasing worldwide. Impaired lung function might be associated with cognitive decline in older age; however, results from large longitudinal studies are lacking. In this study, we examined the longitudinal associations between pul...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Experimental Gerontology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556524000287 |
| _version_ | 1797220629351497728 |
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| author | Albert J. Ksinan Andrea Dalecká Tatyana Court Hynek Pikhart Martin Bobák |
| author_facet | Albert J. Ksinan Andrea Dalecká Tatyana Court Hynek Pikhart Martin Bobák |
| author_sort | Albert J. Ksinan |
| collection | DOAJ |
| description | Background: The number of older people with cognitive impairment is increasing worldwide. Impaired lung function might be associated with cognitive decline in older age; however, results from large longitudinal studies are lacking. In this study, we examined the longitudinal associations between pulmonary function and the trajectories of cognitive decline using prospective population-based SHARE data from 14 countries. Methods: The analytic sample included N = 32,049 older adults (Mean age at baseline = 64.76 years). The dependent variable was cognitive performance, measured repeatedly across six waves in three domains: verbal fluency, memory, and numeracy. The main predictor of interest was peak expiratory flow (PEF). The data were analyzed in a multilevel accelerated longitudinal design, with models adjusted for a variety of covariates. Results: A lower PEF score was associated with lower cognitive performance for each domain as well as a lower global cognitive score. These associations remained statistically significant after adjusting for all covariates Q4 vs Q1 verbal fluency: unstandardized coefficient B = -3.15; numeracy: B = -0.52; memory: B = -0.64; global cognitive score B = −2.65, all p < .001). However, the PEF score was not found to be associated with the rate of decline for either of the cognitive outcomes. Conclusions: In this large multi-national longitudinal study, the PEF score was independently associated with lower levels of cognitive functions, but it did not predict a future decline. The results suggest that pre-existing differences in lung functions are responsible for variability in cognitive functions and that these differences remained stable across aging. |
| first_indexed | 2024-04-24T12:52:35Z |
| format | Article |
| id | doaj.art-c8fe1f40956f41eead2652488b653a7e |
| institution | Directory Open Access Journal |
| issn | 1873-6815 |
| language | English |
| last_indexed | 2024-04-24T12:52:35Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj.art-c8fe1f40956f41eead2652488b653a7e2024-04-06T04:39:25ZengElsevierExperimental Gerontology1873-68152024-05-01189112386Pulmonary function and trajectories of cognitive decline in aging populationAlbert J. Ksinan0Andrea Dalecká1Tatyana Court2Hynek Pikhart3Martin Bobák4RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic; Corresponding author at: RECETOX, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.RECETOX, Faculty of Science, Masaryk University, Brno, Czech RepublicRECETOX, Faculty of Science, Masaryk University, Brno, Czech RepublicRECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic; Department of Epidemiology & Public Health, University College London, Institute of Epidemiology and Health Care, London, UKRECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic; Department of Epidemiology & Public Health, University College London, Institute of Epidemiology and Health Care, London, UKBackground: The number of older people with cognitive impairment is increasing worldwide. Impaired lung function might be associated with cognitive decline in older age; however, results from large longitudinal studies are lacking. In this study, we examined the longitudinal associations between pulmonary function and the trajectories of cognitive decline using prospective population-based SHARE data from 14 countries. Methods: The analytic sample included N = 32,049 older adults (Mean age at baseline = 64.76 years). The dependent variable was cognitive performance, measured repeatedly across six waves in three domains: verbal fluency, memory, and numeracy. The main predictor of interest was peak expiratory flow (PEF). The data were analyzed in a multilevel accelerated longitudinal design, with models adjusted for a variety of covariates. Results: A lower PEF score was associated with lower cognitive performance for each domain as well as a lower global cognitive score. These associations remained statistically significant after adjusting for all covariates Q4 vs Q1 verbal fluency: unstandardized coefficient B = -3.15; numeracy: B = -0.52; memory: B = -0.64; global cognitive score B = −2.65, all p < .001). However, the PEF score was not found to be associated with the rate of decline for either of the cognitive outcomes. Conclusions: In this large multi-national longitudinal study, the PEF score was independently associated with lower levels of cognitive functions, but it did not predict a future decline. The results suggest that pre-existing differences in lung functions are responsible for variability in cognitive functions and that these differences remained stable across aging.http://www.sciencedirect.com/science/article/pii/S0531556524000287Pulmonary functionPeak expiratory flowCognitive declineCross-culturalLongitudinal |
| spellingShingle | Albert J. Ksinan Andrea Dalecká Tatyana Court Hynek Pikhart Martin Bobák Pulmonary function and trajectories of cognitive decline in aging population Experimental Gerontology Pulmonary function Peak expiratory flow Cognitive decline Cross-cultural Longitudinal |
| title | Pulmonary function and trajectories of cognitive decline in aging population |
| title_full | Pulmonary function and trajectories of cognitive decline in aging population |
| title_fullStr | Pulmonary function and trajectories of cognitive decline in aging population |
| title_full_unstemmed | Pulmonary function and trajectories of cognitive decline in aging population |
| title_short | Pulmonary function and trajectories of cognitive decline in aging population |
| title_sort | pulmonary function and trajectories of cognitive decline in aging population |
| topic | Pulmonary function Peak expiratory flow Cognitive decline Cross-cultural Longitudinal |
| url | http://www.sciencedirect.com/science/article/pii/S0531556524000287 |
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