Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior
Summary: Reward-predictive cues acquire motivating and reinforcing properties that contribute to the escalation and relapse of drug use in addiction. The ventral pallidum (VP) and ventral tegmental area (VTA) are two key nodes in brain reward circuitry implicated in addiction and cue-driven behavior...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723016807 |
| _version_ | 1797361389921107968 |
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| author | Dakota Palmer Christelle A. Cayton Alexandra Scott Iris Lin Bailey Newell Anika Paulson Morgan Weberg Jocelyn M. Richard |
| author_facet | Dakota Palmer Christelle A. Cayton Alexandra Scott Iris Lin Bailey Newell Anika Paulson Morgan Weberg Jocelyn M. Richard |
| author_sort | Dakota Palmer |
| collection | DOAJ |
| description | Summary: Reward-predictive cues acquire motivating and reinforcing properties that contribute to the escalation and relapse of drug use in addiction. The ventral pallidum (VP) and ventral tegmental area (VTA) are two key nodes in brain reward circuitry implicated in addiction and cue-driven behavior. In the current study, we use in vivo fiber photometry and optogenetics to record from and manipulate VP→VTA in rats performing a discriminative stimulus task to determine the role these neurons play in invigoration and reinforcement by reward cues. We find that VP→VTA neurons are active during reward consumption and that optogenetic stimulation of these neurons biases choice behavior and is reinforcing. Critically, we find no encoding of reward-seeking vigor, and optogenetic stimulation does not enhance the probability or vigor of reward seeking in response to cues. Our results suggest that VP→VTA activity is more important for reinforcement than for invigoration of reward seeking by cues. |
| first_indexed | 2024-03-08T15:53:00Z |
| format | Article |
| id | doaj.art-c9031a41ff504da594d7a4d7b2c85259 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-08T15:53:00Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-c9031a41ff504da594d7a4d7b2c852592024-01-09T04:04:22ZengElsevierCell Reports2211-12472024-01-01431113669Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behaviorDakota Palmer0Christelle A. Cayton1Alexandra Scott2Iris Lin3Bailey Newell4Anika Paulson5Morgan Weberg6Jocelyn M. Richard7Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USAMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USAMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USAMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USAMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USAMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USADepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USAMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Corresponding authorSummary: Reward-predictive cues acquire motivating and reinforcing properties that contribute to the escalation and relapse of drug use in addiction. The ventral pallidum (VP) and ventral tegmental area (VTA) are two key nodes in brain reward circuitry implicated in addiction and cue-driven behavior. In the current study, we use in vivo fiber photometry and optogenetics to record from and manipulate VP→VTA in rats performing a discriminative stimulus task to determine the role these neurons play in invigoration and reinforcement by reward cues. We find that VP→VTA neurons are active during reward consumption and that optogenetic stimulation of these neurons biases choice behavior and is reinforcing. Critically, we find no encoding of reward-seeking vigor, and optogenetic stimulation does not enhance the probability or vigor of reward seeking in response to cues. Our results suggest that VP→VTA activity is more important for reinforcement than for invigoration of reward seeking by cues.http://www.sciencedirect.com/science/article/pii/S2211124723016807CP: NeuroscienceCP: Cell biology |
| spellingShingle | Dakota Palmer Christelle A. Cayton Alexandra Scott Iris Lin Bailey Newell Anika Paulson Morgan Weberg Jocelyn M. Richard Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior Cell Reports CP: Neuroscience CP: Cell biology |
| title | Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior |
| title_full | Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior |
| title_fullStr | Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior |
| title_full_unstemmed | Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior |
| title_short | Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior |
| title_sort | ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward seeking behavior |
| topic | CP: Neuroscience CP: Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723016807 |
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