Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition

Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition

Abstract Background Osteoarthritis (OA) is a common degenerative joint disease characterized by persistent articular cartilage degeneration and synovitis. Oxymatrine (OMT) is a quinzolazine alkaloid extracted from the traditional Chinese medicine, matrine, and possesses anti-inflammatory properties...

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Bibliographic Details
Main Authors: Jinying Lu, Jiang Bian, Yutong Wang, Yan Zhao, Xinmin Zhao, Gao Wang, Jing Yang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Oxymatrine
interleukin-1β
Chondrocytes
AKT/mTOR pathway
Autophagy
Online Access:https://doi.org/10.1186/s13018-024-04667-2

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