Metronidazole-Induced Bullous Pemphigoid: A Case Report
Bullous pemphigoid is an autoimmune cutaneous blistering disorder, the exact pathogenesis of which is still not fully elucidated. Drug-induced bullous pemphigoid eruptions are rare but have been reported earlier with the use of frusemide, psoralens, ibuprofen, galantamine hydrobromide, ACE inhibit...
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JCDR Research and Publications Private Limited
2015-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/6972/14669_CE(Ra1)_F(GH)_PF1(VIAK)_PFA(AK)_PF2(PAG).pdf |
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| author | Saibal Moitra Sukanta Sen Indranil Banerjee Ayan Sikder Prasanta Das |
| author_facet | Saibal Moitra Sukanta Sen Indranil Banerjee Ayan Sikder Prasanta Das |
| author_sort | Saibal Moitra |
| collection | DOAJ |
| description | Bullous pemphigoid is an autoimmune cutaneous blistering disorder, the exact pathogenesis of which is still not fully elucidated.
Drug-induced bullous pemphigoid eruptions are rare but have been reported earlier with the use of frusemide, psoralens, ibuprofen,
galantamine hydrobromide, ACE inhibitors like captopril, spironolactone, penicillin, ampicillin, levofloxacin, penicillamine. We hereby
report a case of metronidazole induced bullous pemphigoid (BP) in a 52-year-old male patient suffering from liver abscess following 4
days of drug administration. The skin biopsy findings obtained from the patient were consistent with the diagnosis of bullous pemphigoid
(BP). Metronidazole was discontinued and symptomatic treatment was offered to the patient. Following withdrawal of metronidazole, the
bullae subsided in the next 7-10 days without any significant residual scarring. The causality assessment performed as per the Naranjo
algorithm revealed the case to be probable (Naranjo score 7). |
| first_indexed | 2024-12-12T23:03:14Z |
| format | Article |
| id | doaj.art-c9064c8b0afb4b8c965b0186dbab77f9 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-12T23:03:14Z |
| publishDate | 2015-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-c9064c8b0afb4b8c965b0186dbab77f92022-12-22T00:08:47ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-12-01912FD01FD0310.7860/JCDR/2015/14669.6972Metronidazole-Induced Bullous Pemphigoid: A Case ReportSaibal Moitra0Sukanta Sen1Indranil Banerjee2Ayan Sikder3Prasanta Das4Pulmonologist, Department of Pulmonary Medicine, Charnock Hospital & Research Centre Pvt. Ltd., Kolkata, West Bengal, India.Associate Professor, Department of Pharmacology, ICARE Institute of Medical Sciences & Research, Haldia, West Bengal, India.Assistant Professor, Department of Pharmacology, Lady Hardinge Medical College, New Delhi, India.ICU Registrar, Department of Emergency Medicine, Chittaranjan Seva Sadan, Bhawanipur, Kolkata, West Bengal, India.Respiratory Therapist, Department of Pulmonary Medicine, Charnock Hospital & Research Centre Pvt. Ltd., Kolkata, West Bengal, India.Bullous pemphigoid is an autoimmune cutaneous blistering disorder, the exact pathogenesis of which is still not fully elucidated. Drug-induced bullous pemphigoid eruptions are rare but have been reported earlier with the use of frusemide, psoralens, ibuprofen, galantamine hydrobromide, ACE inhibitors like captopril, spironolactone, penicillin, ampicillin, levofloxacin, penicillamine. We hereby report a case of metronidazole induced bullous pemphigoid (BP) in a 52-year-old male patient suffering from liver abscess following 4 days of drug administration. The skin biopsy findings obtained from the patient were consistent with the diagnosis of bullous pemphigoid (BP). Metronidazole was discontinued and symptomatic treatment was offered to the patient. Following withdrawal of metronidazole, the bullae subsided in the next 7-10 days without any significant residual scarring. The causality assessment performed as per the Naranjo algorithm revealed the case to be probable (Naranjo score 7).https://jcdr.net/articles/PDF/6972/14669_CE(Ra1)_F(GH)_PF1(VIAK)_PFA(AK)_PF2(PAG).pdfadverse drug reactioncutaneous drug eruptionsdrug-induced bullous pemphigoid |
| spellingShingle | Saibal Moitra Sukanta Sen Indranil Banerjee Ayan Sikder Prasanta Das Metronidazole-Induced Bullous Pemphigoid: A Case Report Journal of Clinical and Diagnostic Research adverse drug reaction cutaneous drug eruptions drug-induced bullous pemphigoid |
| title | Metronidazole-Induced Bullous Pemphigoid: A Case Report |
| title_full | Metronidazole-Induced Bullous Pemphigoid: A Case Report |
| title_fullStr | Metronidazole-Induced Bullous Pemphigoid: A Case Report |
| title_full_unstemmed | Metronidazole-Induced Bullous Pemphigoid: A Case Report |
| title_short | Metronidazole-Induced Bullous Pemphigoid: A Case Report |
| title_sort | metronidazole induced bullous pemphigoid a case report |
| topic | adverse drug reaction cutaneous drug eruptions drug-induced bullous pemphigoid |
| url | https://jcdr.net/articles/PDF/6972/14669_CE(Ra1)_F(GH)_PF1(VIAK)_PFA(AK)_PF2(PAG).pdf |
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