Role of the neuroendocrine complex in immunotropic effects of nitrogenous metabolites in rats
<p class="MsoNormal"><strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold; font-size: 12,0000pt;">Background. </span></strong><span class="15" style="mso-spacerun:...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2021-03-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/34043 |
| _version_ | 1831762376818425856 |
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| author | Igor Kuchma Anatoliy Gozhenko Igor-Severyn Flyunt Sofiya Ruzhylo Galyna Kovalchuk Walery Zukow Igor Popovych |
| author_facet | Igor Kuchma Anatoliy Gozhenko Igor-Severyn Flyunt Sofiya Ruzhylo Galyna Kovalchuk Walery Zukow Igor Popovych |
| author_sort | Igor Kuchma |
| collection | DOAJ |
| description | <p class="MsoNormal"><strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold; font-size: 12,0000pt;">Background. </span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">We have previously shown that nitrogenous metabolites</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">have immunomodulatory effects, both suppressor and enhancing,</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">both in healthy rats and in humans exposed to pathogenic influences. The immunomodulatory effect of bilirubin is probably mediated through aryl hydrocarbon receptors, and uric acid through TL- and </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">a</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">denosine receptors of immune cells. The question of mediators of the immunomodulatory action of urea and creatinine remains open. We hypothesized the mediating role of mediators of the autonomic nervous system and </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">adaptive </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">hormones.</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">The </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">aim</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> of this study is to analyze the relationships between the parameters of nitrogenous metabolites and the parameters of the autonomic nervous and endocrine systems, on the one hand, and between neuroendocrine and immune parameters - on the other hand. </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Material and methods</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">Experiment was performed on </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">60</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> healthy female Wistar rats. The plasma levels and urinary excretion of the nitrogenous metabolites, HRV and endocrine (corticosterone, triiodothyronine and testosterone plasma levels, calcitonin, parathyroid and mineralocorticoid activities, the thickness of glomerular, fascicular, reticular and medullar zones of adrenals) parameters as well as parameters of immunity were determined</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">. </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Results</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">According to the results of canonical correlation analysis, the modulating effects of nitrogenous metabolites on neuroendocrine parameters are quite pronounced and almost identical in terms of bilirubin</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(R=0,603)</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">, creatinine </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(R=0,602)</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">, uric acid </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(R=0,599) </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">and urea </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(R=0,586)</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">.</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">Taken together, nitrogenous metabolites determine neuroendocrine parameters by 7</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">1,5</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">%</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> (</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">R=0,845; χ</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">2</span></sup><sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: sub;">(84)</span></sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">=179; p<10</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">-6</span></sup><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">)</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">Triiodothyronine, fascicular and medullar areas of the adrenal glands, vagal tone and calcitonin activity were the most susceptible to nitrogenous metabolites. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">I</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">n turn, neuroendocrine parameters determine the parameters of immunity, subject to exposure to nitrogenous metabolites, by 95,8% </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">R=0,979; χ</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">2</span></sup><sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: sub;">(264)</span></sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">=405; p<10</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">-6</span></sup><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">)</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">.</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Conclusion</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">Previously identified immunomodulatory effects of nitrogenous metabolites are realized, perhaps, through the factors of the autonomic nervous and endocrine systems.</span></p> |
| first_indexed | 2024-12-22T05:05:53Z |
| format | Article |
| id | doaj.art-c9070da1a78346b0b0eeffa2cdf0562c |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-22T05:05:53Z |
| publishDate | 2021-03-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-c9070da1a78346b0b0eeffa2cdf0562c2022-12-21T18:38:07ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062021-03-0111321223010.12775/JEHS.2021.11.03.02127253Role of the neuroendocrine complex in immunotropic effects of nitrogenous metabolites in ratsIgor Kuchma0Anatoliy Gozhenko1Igor-Severyn Flyunt2Sofiya Ruzhylo3Galyna Kovalchuk4Walery Zukow5Igor Popovych6Ukrainian Scientific Research Institute for Medicine of Transport, OdesaUkrainian Scientific Research Institute for Medicine of Transport, OdesaIvan Franko Pedagogical University, DrohobychIvan Franko Pedagogical University, DrohobychIvan Franko Pedagogical University, DrohobychNicolaus Copernicus University, TorunUkrainian Scientific Research Institute for Medicine of Transport, Odesa Bohomolets’ OO Institute of Physiology of National Academy of Sciences, Kyїv<p class="MsoNormal"><strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold; font-size: 12,0000pt;">Background. </span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">We have previously shown that nitrogenous metabolites</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">have immunomodulatory effects, both suppressor and enhancing,</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">both in healthy rats and in humans exposed to pathogenic influences. The immunomodulatory effect of bilirubin is probably mediated through aryl hydrocarbon receptors, and uric acid through TL- and </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">a</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">denosine receptors of immune cells. The question of mediators of the immunomodulatory action of urea and creatinine remains open. We hypothesized the mediating role of mediators of the autonomic nervous system and </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">adaptive </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">hormones.</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">The </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">aim</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> of this study is to analyze the relationships between the parameters of nitrogenous metabolites and the parameters of the autonomic nervous and endocrine systems, on the one hand, and between neuroendocrine and immune parameters - on the other hand. </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Material and methods</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">Experiment was performed on </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">60</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> healthy female Wistar rats. The plasma levels and urinary excretion of the nitrogenous metabolites, HRV and endocrine (corticosterone, triiodothyronine and testosterone plasma levels, calcitonin, parathyroid and mineralocorticoid activities, the thickness of glomerular, fascicular, reticular and medullar zones of adrenals) parameters as well as parameters of immunity were determined</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">. </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Results</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">According to the results of canonical correlation analysis, the modulating effects of nitrogenous metabolites on neuroendocrine parameters are quite pronounced and almost identical in terms of bilirubin</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(R=0,603)</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">, creatinine </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(R=0,602)</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">, uric acid </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(R=0,599) </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">and urea </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(R=0,586)</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">.</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">Taken together, nitrogenous metabolites determine neuroendocrine parameters by 7</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">1,5</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">%</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> (</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">R=0,845; χ</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">2</span></sup><sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: sub;">(84)</span></sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">=179; p<10</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">-6</span></sup><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">)</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">Triiodothyronine, fascicular and medullar areas of the adrenal glands, vagal tone and calcitonin activity were the most susceptible to nitrogenous metabolites. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">I</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">n turn, neuroendocrine parameters determine the parameters of immunity, subject to exposure to nitrogenous metabolites, by 95,8% </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">R=0,979; χ</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">2</span></sup><sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: sub;">(264)</span></sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">=405; p<10</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">-6</span></sup><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">)</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">.</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Conclusion</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">Previously identified immunomodulatory effects of nitrogenous metabolites are realized, perhaps, through the factors of the autonomic nervous and endocrine systems.</span></p>https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/34043uric acidcreatinineureabilirubinneuro-endocrine parametersrelationshipsrats. |
| spellingShingle | Igor Kuchma Anatoliy Gozhenko Igor-Severyn Flyunt Sofiya Ruzhylo Galyna Kovalchuk Walery Zukow Igor Popovych Role of the neuroendocrine complex in immunotropic effects of nitrogenous metabolites in rats Journal of Education, Health and Sport uric acid creatinine urea bilirubin neuro-endocrine parameters relationships rats. |
| title | Role of the neuroendocrine complex in immunotropic effects of nitrogenous metabolites in rats |
| title_full | Role of the neuroendocrine complex in immunotropic effects of nitrogenous metabolites in rats |
| title_fullStr | Role of the neuroendocrine complex in immunotropic effects of nitrogenous metabolites in rats |
| title_full_unstemmed | Role of the neuroendocrine complex in immunotropic effects of nitrogenous metabolites in rats |
| title_short | Role of the neuroendocrine complex in immunotropic effects of nitrogenous metabolites in rats |
| title_sort | role of the neuroendocrine complex in immunotropic effects of nitrogenous metabolites in rats |
| topic | uric acid creatinine urea bilirubin neuro-endocrine parameters relationships rats. |
| url | https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/34043 |
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