Does Maternal Hemoglobin Consistently Associate with Iron Status at Birth? Evidence from a Cross-sectional Study in Indonesia
Background: Maternal iron status is a vital determinant of feto-maternal iron transfer to ensure the adequacy of neonatal iron. Hemoglobin measurement is often used in pregnancy as an iron status parameter. However, evidence on the association between maternal hemoglobin and newborn iron status is s...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-01-01
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| Series: | Iranian Journal of Neonatology |
| Subjects: | |
| Online Access: | https://ijn.mums.ac.ir/article_21697_0f6757478ea9032668f30fb00782398f.pdf |
| _version_ | 1797832723062063104 |
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| author | Qodri Santosa Alfi Muntafiah Lantip Rujito Joko Mulyanto |
| author_facet | Qodri Santosa Alfi Muntafiah Lantip Rujito Joko Mulyanto |
| author_sort | Qodri Santosa |
| collection | DOAJ |
| description | Background: Maternal iron status is a vital determinant of feto-maternal iron transfer to ensure the adequacy of neonatal iron. Hemoglobin measurement is often used in pregnancy as an iron status parameter. However, evidence on the association between maternal hemoglobin and newborn iron status is still inconclusive. This study aims to assess the association between maternal hemoglobin and neonatal iron status.Methods: We conducted a cross-sectional study involving 84 neonates and their mothers in three hospitals in Central Java, Indonesia. Maternal hemoglobin was measured as a proxy for maternal iron status. Neonatal iron status was measured using hematologic markers (red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, and red cell distribution) and biochemical markers (serum iron, soluble transferrin receptor/sTfR, and cord blood hepcidin). Neonatal iron status was compared between the two groups of maternal iron status followed by sensitivity analysis.Results: Maternal hemoglobin was not significantly associated with neonatal hematologic markers or biochemical markers. Sensitivity analysis did not reveal any associations in multiple tests conducted by various categories.Conclusion: Maternal hemoglobin was consistently not associated with neonatal iron status, as measured by both hematologic and biochemical markers. The use of maternal hemoglobin as a single parameter proxy for maternal and neonatal iron status is likely inaccurate and can potentially underestimate the actual maternal and neonatal iron status. |
| first_indexed | 2024-04-09T14:12:23Z |
| format | Article |
| id | doaj.art-c9073ecc6ecb41ecadfcc89bc45f924f |
| institution | Directory Open Access Journal |
| issn | 2251-7510 2322-2158 |
| language | English |
| last_indexed | 2024-04-09T14:12:23Z |
| publishDate | 2023-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Neonatology |
| spelling | doaj.art-c9073ecc6ecb41ecadfcc89bc45f924f2023-05-06T06:31:19ZengMashhad University of Medical SciencesIranian Journal of Neonatology2251-75102322-21582023-01-01141465310.22038/ijn.2023.65752.228121697Does Maternal Hemoglobin Consistently Associate with Iron Status at Birth? Evidence from a Cross-sectional Study in IndonesiaQodri Santosa0Alfi Muntafiah1Lantip Rujito2Joko Mulyanto3Department of Child Health, Faculty of Medicine, Universitas Jenderal Soedirman, Purwokerto, IndonesiaDepartment of Biochemistry, Faculty of Medicine, Universitas Jenderal Soedirman, Purwokerto, IndonesiaDepartment of Molecular Biology, Faculty of Medicine, Universitas Jenderal Soedirman, Purwokerto, IndonesiaDepartment of Public Health and Community Medicine, Faculty of Medicine, Universitas Jenderal Soedirman, Purwokerto, IndonesiaBackground: Maternal iron status is a vital determinant of feto-maternal iron transfer to ensure the adequacy of neonatal iron. Hemoglobin measurement is often used in pregnancy as an iron status parameter. However, evidence on the association between maternal hemoglobin and newborn iron status is still inconclusive. This study aims to assess the association between maternal hemoglobin and neonatal iron status.Methods: We conducted a cross-sectional study involving 84 neonates and their mothers in three hospitals in Central Java, Indonesia. Maternal hemoglobin was measured as a proxy for maternal iron status. Neonatal iron status was measured using hematologic markers (red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, and red cell distribution) and biochemical markers (serum iron, soluble transferrin receptor/sTfR, and cord blood hepcidin). Neonatal iron status was compared between the two groups of maternal iron status followed by sensitivity analysis.Results: Maternal hemoglobin was not significantly associated with neonatal hematologic markers or biochemical markers. Sensitivity analysis did not reveal any associations in multiple tests conducted by various categories.Conclusion: Maternal hemoglobin was consistently not associated with neonatal iron status, as measured by both hematologic and biochemical markers. The use of maternal hemoglobin as a single parameter proxy for maternal and neonatal iron status is likely inaccurate and can potentially underestimate the actual maternal and neonatal iron status.https://ijn.mums.ac.ir/article_21697_0f6757478ea9032668f30fb00782398f.pdfhemoglobinhepcidiniron statusmaternalnewbornstfr |
| spellingShingle | Qodri Santosa Alfi Muntafiah Lantip Rujito Joko Mulyanto Does Maternal Hemoglobin Consistently Associate with Iron Status at Birth? Evidence from a Cross-sectional Study in Indonesia Iranian Journal of Neonatology hemoglobin hepcidin iron status maternal newborn stfr |
| title | Does Maternal Hemoglobin Consistently Associate with Iron Status at Birth? Evidence from a Cross-sectional Study in Indonesia |
| title_full | Does Maternal Hemoglobin Consistently Associate with Iron Status at Birth? Evidence from a Cross-sectional Study in Indonesia |
| title_fullStr | Does Maternal Hemoglobin Consistently Associate with Iron Status at Birth? Evidence from a Cross-sectional Study in Indonesia |
| title_full_unstemmed | Does Maternal Hemoglobin Consistently Associate with Iron Status at Birth? Evidence from a Cross-sectional Study in Indonesia |
| title_short | Does Maternal Hemoglobin Consistently Associate with Iron Status at Birth? Evidence from a Cross-sectional Study in Indonesia |
| title_sort | does maternal hemoglobin consistently associate with iron status at birth evidence from a cross sectional study in indonesia |
| topic | hemoglobin hepcidin iron status maternal newborn stfr |
| url | https://ijn.mums.ac.ir/article_21697_0f6757478ea9032668f30fb00782398f.pdf |
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