Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease

Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease

Neuronal hyperactivity is a key abnormality in early stage Alzheimer's disease (AD). Medial entorhinal cortex (mEC) plays a vital role in memory function and is affected early in AD. Growing evidence indicates benefits of regular exercise on memory and cognitive function in humans with AD, alth...

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Bibliographic Details
Main Authors:	Huimin Chen, Jiajia Cai, Aozhe Wang, Wantang Su, Chunyan Ji, Li Zhao
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Series:	Experimental Gerontology
Subjects:	3xTg-AD mice Alzheimer's disease Exercise Medial entorhinal cortex Neurotransmission Hyperexcitability
Online Access:	http://www.sciencedirect.com/science/article/pii/S0531556523002309

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