CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis
Highlights 1. Pathologically impaired periventricular white matter was observed in NEC neonatal rats. 2. Hypoxic-ischemic brain injury can also lead to intestinal inflammation. 3. CXCL1 and CXCR2 were significantly upregulated in intestinal and brain tissues in NEC, HIBI, and NEC+HIBI rats compared...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-11-01
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Series: | BMC Neuroscience |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12868-022-00749-1 |
Summary: | Highlights 1. Pathologically impaired periventricular white matter was observed in NEC neonatal rats. 2. Hypoxic-ischemic brain injury can also lead to intestinal inflammation. 3. CXCL1 and CXCR2 were significantly upregulated in intestinal and brain tissues in NEC, HIBI, and NEC+HIBI rats compared to the normal group. 4. Compared with the HIBI group, CXCL1 and CXCR2 expression continued to increase in NEC+HIBI rats. |
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ISSN: | 1471-2202 |