CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis

Highlights 1. Pathologically impaired periventricular white matter was observed in NEC neonatal rats. 2. Hypoxic-ischemic brain injury can also lead to intestinal inflammation. 3. CXCL1 and CXCR2 were significantly upregulated in intestinal and brain tissues in NEC, HIBI, and NEC+HIBI rats compared...

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Bibliographic Details
Main Authors: Can Yang, Zhiyuan Feng, Hong Deng, Lu Dai, Ling He, Linlin Yin, Jing Zhao
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Neuroscience
Subjects:
Online Access:https://doi.org/10.1186/s12868-022-00749-1
Description
Summary:Highlights 1. Pathologically impaired periventricular white matter was observed in NEC neonatal rats. 2. Hypoxic-ischemic brain injury can also lead to intestinal inflammation. 3. CXCL1 and CXCR2 were significantly upregulated in intestinal and brain tissues in NEC, HIBI, and NEC+HIBI rats compared to the normal group. 4. Compared with the HIBI group, CXCL1 and CXCR2 expression continued to increase in NEC+HIBI rats.
ISSN:1471-2202