CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis
Highlights 1. Pathologically impaired periventricular white matter was observed in NEC neonatal rats. 2. Hypoxic-ischemic brain injury can also lead to intestinal inflammation. 3. CXCL1 and CXCR2 were significantly upregulated in intestinal and brain tissues in NEC, HIBI, and NEC+HIBI rats compared...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12868-022-00749-1 |
| _version_ | 1811217732607148032 |
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| author | Can Yang Zhiyuan Feng Hong Deng Lu Dai Ling He Linlin Yin Jing Zhao |
| author_facet | Can Yang Zhiyuan Feng Hong Deng Lu Dai Ling He Linlin Yin Jing Zhao |
| author_sort | Can Yang |
| collection | DOAJ |
| description | Highlights 1. Pathologically impaired periventricular white matter was observed in NEC neonatal rats. 2. Hypoxic-ischemic brain injury can also lead to intestinal inflammation. 3. CXCL1 and CXCR2 were significantly upregulated in intestinal and brain tissues in NEC, HIBI, and NEC+HIBI rats compared to the normal group. 4. Compared with the HIBI group, CXCL1 and CXCR2 expression continued to increase in NEC+HIBI rats. |
| first_indexed | 2024-04-12T06:59:35Z |
| format | Article |
| id | doaj.art-c908c65bc1784dd89baea2e313fedd15 |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-04-12T06:59:35Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-c908c65bc1784dd89baea2e313fedd152022-12-22T03:43:03ZengBMCBMC Neuroscience1471-22022022-11-0123111110.1186/s12868-022-00749-1CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axisCan Yang0Zhiyuan Feng1Hong Deng2Lu Dai3Ling He4Linlin Yin5Jing Zhao6Department of Neonatology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Neonatology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Neonatology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Neonatology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Neonatology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Neonatology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Neonatology, Affiliated Hospital of North Sichuan Medical CollegeHighlights 1. Pathologically impaired periventricular white matter was observed in NEC neonatal rats. 2. Hypoxic-ischemic brain injury can also lead to intestinal inflammation. 3. CXCL1 and CXCR2 were significantly upregulated in intestinal and brain tissues in NEC, HIBI, and NEC+HIBI rats compared to the normal group. 4. Compared with the HIBI group, CXCL1 and CXCR2 expression continued to increase in NEC+HIBI rats.https://doi.org/10.1186/s12868-022-00749-1White matter injuryNecrotizing enterocolitisGut–Brain axisCXCL1CXCR2 |
| spellingShingle | Can Yang Zhiyuan Feng Hong Deng Lu Dai Ling He Linlin Yin Jing Zhao CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis BMC Neuroscience White matter injury Necrotizing enterocolitis Gut–Brain axis CXCL1 CXCR2 |
| title | CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis |
| title_full | CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis |
| title_fullStr | CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis |
| title_full_unstemmed | CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis |
| title_short | CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis |
| title_sort | cxcl1 cxcr2 is involved in white matter injury in neonatal rats via the gut brain axis |
| topic | White matter injury Necrotizing enterocolitis Gut–Brain axis CXCL1 CXCR2 |
| url | https://doi.org/10.1186/s12868-022-00749-1 |
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