Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugs
In today's drug development world, combinatorial chemistry, high-throughput screening, and genomics have provided a technologic platform that produces a large number of new chemical entities with therapeutic potential each year. Its outcome the new chemical entities shifted towards higher molec...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-12-01
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| Series: | Future Journal of Pharmaceutical Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2314724517301656 |
| _version_ | 1830357245331767296 |
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| author | Ganesan Poovi Narayanasamy Damodharan |
| author_facet | Ganesan Poovi Narayanasamy Damodharan |
| author_sort | Ganesan Poovi |
| collection | DOAJ |
| description | In today's drug development world, combinatorial chemistry, high-throughput screening, and genomics have provided a technologic platform that produces a large number of new chemical entities with therapeutic potential each year. Its outcome the new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in poor water solubility which primarily affects the bioavailability of orally administered drugs. Hence, the poor aqueous solubility not only limits the drug's biological application but also challenges its pharmaceutical development. This review highlights the significant solubility problem and BCS/BDDCS formulation choices, and importance of lipid nanoparticles (LNPs). Also, this review summarizes the fate of lipid and lipid formulations in the human body, Lymphatic transport of drugs in the human body, Challenges of lipid-based delivery, the role of lipids in the enhancement of bioavailability, Mechanism of Lipid nanoparticles and BCS class II drugs as an ideal candidate for the LNPs formulation with their significant finding in research outcomes reported by the different researchers. Based on the available data, the lipid nanoparticles makes this drug delivery systems as one of the promising delivery systems and will be a solution to the formulation scientist. Also, it complies the key objectives of Green chemistry and sustainable chemistry. Keywords: Solubility, BCS/BDDCS, Lipid nanoparticles, BCS class II drugs |
| first_indexed | 2024-12-20T02:20:13Z |
| format | Article |
| id | doaj.art-c90987318afb4b65931797b8a41c578d |
| institution | Directory Open Access Journal |
| issn | 2314-7245 |
| language | English |
| last_indexed | 2024-12-20T02:20:13Z |
| publishDate | 2018-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-c90987318afb4b65931797b8a41c578d2022-12-21T19:56:50ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72452018-12-0142191205Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugsGanesan Poovi0Narayanasamy Damodharan1Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, 603203, Kanchipuram, Tamil Nadu, India; Department of Pharmaceutics, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Puducherry, 605006, India; Corresponding author. Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, 603203, Kanchipuram, Tamil Nadu, IndiaDepartment of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, 603203, Kanchipuram, Tamil Nadu, India; Corresponding author.In today's drug development world, combinatorial chemistry, high-throughput screening, and genomics have provided a technologic platform that produces a large number of new chemical entities with therapeutic potential each year. Its outcome the new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in poor water solubility which primarily affects the bioavailability of orally administered drugs. Hence, the poor aqueous solubility not only limits the drug's biological application but also challenges its pharmaceutical development. This review highlights the significant solubility problem and BCS/BDDCS formulation choices, and importance of lipid nanoparticles (LNPs). Also, this review summarizes the fate of lipid and lipid formulations in the human body, Lymphatic transport of drugs in the human body, Challenges of lipid-based delivery, the role of lipids in the enhancement of bioavailability, Mechanism of Lipid nanoparticles and BCS class II drugs as an ideal candidate for the LNPs formulation with their significant finding in research outcomes reported by the different researchers. Based on the available data, the lipid nanoparticles makes this drug delivery systems as one of the promising delivery systems and will be a solution to the formulation scientist. Also, it complies the key objectives of Green chemistry and sustainable chemistry. Keywords: Solubility, BCS/BDDCS, Lipid nanoparticles, BCS class II drugshttp://www.sciencedirect.com/science/article/pii/S2314724517301656 |
| spellingShingle | Ganesan Poovi Narayanasamy Damodharan Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugs Future Journal of Pharmaceutical Sciences |
| title | Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugs |
| title_full | Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugs |
| title_fullStr | Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugs |
| title_full_unstemmed | Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugs |
| title_short | Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugs |
| title_sort | lipid nanoparticles a challenging approach for oral delivery of bcs class ii drugs |
| url | http://www.sciencedirect.com/science/article/pii/S2314724517301656 |
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