Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences
Whilst it is universally accepted that the energy support of the brain is glucose, the form in which the glucose is taken up by neurones is the topic of intense debate. In the last few decades, the concept of lactate shuttling between glial elements and neural elements has emerged in which the glial...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/10/11/183 |
| _version_ | 1797547372264292352 |
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| author | Carolyn L. Powell Anna R. Davidson Angus M. Brown |
| author_facet | Carolyn L. Powell Anna R. Davidson Angus M. Brown |
| author_sort | Carolyn L. Powell |
| collection | DOAJ |
| description | Whilst it is universally accepted that the energy support of the brain is glucose, the form in which the glucose is taken up by neurones is the topic of intense debate. In the last few decades, the concept of lactate shuttling between glial elements and neural elements has emerged in which the glial cells glycolytically metabolise glucose/glycogen to lactate, which is shuttled to the neural elements via the extracellular fluid. The process occurs during periods of compromised glucose availability where glycogen stored in astrocytes provides lactate to the neurones, and is an integral part of the formation of learning and memory where the energy intensive process of learning requires neuronal lactate uptake provided by astrocytes. More recently sleep, myelination and motor end plate integrity have been shown to involve lactate shuttling. The sequential aspect of lactate production in the astrocyte followed by transport to the neurones is vulnerable to interruption and it is reported that such disparate pathological conditions as Alzheimer’s disease, amyotrophic lateral sclerosis, depression and schizophrenia show disrupted lactate signalling between glial cells and neurones. |
| first_indexed | 2024-03-10T14:43:17Z |
| format | Article |
| id | doaj.art-c90b5d407a2e4928b15ee0e43dffc142 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T14:43:17Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-c90b5d407a2e4928b15ee0e43dffc1422023-11-20T21:36:50ZengMDPI AGBiosensors2079-63742020-11-01101118310.3390/bios10110183Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological ConsequencesCarolyn L. Powell0Anna R. Davidson1Angus M. Brown2School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UKSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UKSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UKWhilst it is universally accepted that the energy support of the brain is glucose, the form in which the glucose is taken up by neurones is the topic of intense debate. In the last few decades, the concept of lactate shuttling between glial elements and neural elements has emerged in which the glial cells glycolytically metabolise glucose/glycogen to lactate, which is shuttled to the neural elements via the extracellular fluid. The process occurs during periods of compromised glucose availability where glycogen stored in astrocytes provides lactate to the neurones, and is an integral part of the formation of learning and memory where the energy intensive process of learning requires neuronal lactate uptake provided by astrocytes. More recently sleep, myelination and motor end plate integrity have been shown to involve lactate shuttling. The sequential aspect of lactate production in the astrocyte followed by transport to the neurones is vulnerable to interruption and it is reported that such disparate pathological conditions as Alzheimer’s disease, amyotrophic lateral sclerosis, depression and schizophrenia show disrupted lactate signalling between glial cells and neurones.https://www.mdpi.com/2079-6374/10/11/183lactateglucoseglycogenastrocyteneuronemonocarboxylate transporter |
| spellingShingle | Carolyn L. Powell Anna R. Davidson Angus M. Brown Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences Biosensors lactate glucose glycogen astrocyte neurone monocarboxylate transporter |
| title | Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences |
| title_full | Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences |
| title_fullStr | Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences |
| title_full_unstemmed | Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences |
| title_short | Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences |
| title_sort | universal glia to neurone lactate transfer in the nervous system physiological functions and pathological consequences |
| topic | lactate glucose glycogen astrocyte neurone monocarboxylate transporter |
| url | https://www.mdpi.com/2079-6374/10/11/183 |
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