Health-related quality of life in outpatients with chronic liver disease: a cross-sectional study
Abstract Background The symptoms and complications related to chronic liver disease (CLD) have been shown to affect patient well-being. Currently there is limited research data on how CLD severity may affect both health-related quality of life (HRQOL) and the development of depressive symptoms in CL...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-021-01890-7 |
| _version_ | 1818606823638302720 |
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| author | Domenica Gazineo Lea Godino Virna Bui Latifa El Mouttaqi Eugenia Franciosi Alessandra Natalino Grazia Ceci Elisa Ambrosi |
| author_facet | Domenica Gazineo Lea Godino Virna Bui Latifa El Mouttaqi Eugenia Franciosi Alessandra Natalino Grazia Ceci Elisa Ambrosi |
| author_sort | Domenica Gazineo |
| collection | DOAJ |
| description | Abstract Background The symptoms and complications related to chronic liver disease (CLD) have been shown to affect patient well-being. Currently there is limited research data on how CLD severity may affect both health-related quality of life (HRQOL) and the development of depressive symptoms in CLD patients. Moreover, the ongoing advances in CLD treatment, and its effect on HRQOL, highlight the need for further studies. Therefore, the aim of the present study was to evaluate if the CLD severity may affect the HRQOL and the development of depressive symptoms. Methods A cross-sectional study was conducted. Patients with CLDs were identified at their regular visits to the outpatient clinic of the Sant’Orsola-Malpighi Hospital in Bologna, between September 2016 and July 2017. HRQOL was measured with Short Form 12 (SF-12) and Nottingham Health Profile (NHP) questionnaires; depressive symptoms were measured with Beck Depression Inventory-II (BDI). CLD severity was measured using the MELD score and the sample was stratified into five classes according to it. Group comparisons were conducted using the Kruskal–Wallis test. Results Two hundred and fifty-four patients were included. Mean age was 62.84 years (SD 11.75) and 57.9% were male. Most participants were affected by compensated cirrhosis (140.2%) and chronic hepatitis (40.2%), with a disease duration ≥ 5 years (69.3%). Regarding the MELD score, 67.7% of patients belonged to Class I, 29.9% to Class II, and 2.4% to Class III. There were not patients belonging to the Classes IV and V. No statistically significant differences were found in all SF-12 and NHP domains between the MELD classes, except for CLD impact on sexual life and holidays (p = 0.037 and p = 0.032, respectively). A prevalence rate of 26% of depressive symptoms was reported, no statistically significant differences were found in BDI-II total scores between the three MELD classes. Conclusions All domains of HRQOL and depression were altered in CLDs patients, nevertheless CLD severity was not confirmed as an affecting factor for HRQOL. |
| first_indexed | 2024-12-16T14:16:59Z |
| format | Article |
| id | doaj.art-c90b9b603bbb446d92e9d452e36a9af0 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-16T14:16:59Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-c90b9b603bbb446d92e9d452e36a9af02022-12-21T22:28:35ZengBMCBMC Gastroenterology1471-230X2021-08-012111910.1186/s12876-021-01890-7Health-related quality of life in outpatients with chronic liver disease: a cross-sectional studyDomenica Gazineo0Lea Godino1Virna Bui2Latifa El Mouttaqi3Eugenia Franciosi4Alessandra Natalino5Grazia Ceci6Elisa Ambrosi7Azienda Ospedaliero-Universitaria S. Orsola-MalpighiAzienda Ospedaliero-Universitaria S. Orsola-MalpighiAzienda Ospedaliero-Universitaria S. Orsola-MalpighiAzienda Ospedaliero-Universitaria S. Orsola-MalpighiAzienda USLAzienda USLAzienda Ospedaliero-Universitaria S. Orsola-MalpighiDepartment of Diagnostics and Public Health, University of VeronaAbstract Background The symptoms and complications related to chronic liver disease (CLD) have been shown to affect patient well-being. Currently there is limited research data on how CLD severity may affect both health-related quality of life (HRQOL) and the development of depressive symptoms in CLD patients. Moreover, the ongoing advances in CLD treatment, and its effect on HRQOL, highlight the need for further studies. Therefore, the aim of the present study was to evaluate if the CLD severity may affect the HRQOL and the development of depressive symptoms. Methods A cross-sectional study was conducted. Patients with CLDs were identified at their regular visits to the outpatient clinic of the Sant’Orsola-Malpighi Hospital in Bologna, between September 2016 and July 2017. HRQOL was measured with Short Form 12 (SF-12) and Nottingham Health Profile (NHP) questionnaires; depressive symptoms were measured with Beck Depression Inventory-II (BDI). CLD severity was measured using the MELD score and the sample was stratified into five classes according to it. Group comparisons were conducted using the Kruskal–Wallis test. Results Two hundred and fifty-four patients were included. Mean age was 62.84 years (SD 11.75) and 57.9% were male. Most participants were affected by compensated cirrhosis (140.2%) and chronic hepatitis (40.2%), with a disease duration ≥ 5 years (69.3%). Regarding the MELD score, 67.7% of patients belonged to Class I, 29.9% to Class II, and 2.4% to Class III. There were not patients belonging to the Classes IV and V. No statistically significant differences were found in all SF-12 and NHP domains between the MELD classes, except for CLD impact on sexual life and holidays (p = 0.037 and p = 0.032, respectively). A prevalence rate of 26% of depressive symptoms was reported, no statistically significant differences were found in BDI-II total scores between the three MELD classes. Conclusions All domains of HRQOL and depression were altered in CLDs patients, nevertheless CLD severity was not confirmed as an affecting factor for HRQOL.https://doi.org/10.1186/s12876-021-01890-7Chronic liver diseaseHealth-related quality of lifeDepressive symptomsSurveys and QuestionnairesCross-sectional studies |
| spellingShingle | Domenica Gazineo Lea Godino Virna Bui Latifa El Mouttaqi Eugenia Franciosi Alessandra Natalino Grazia Ceci Elisa Ambrosi Health-related quality of life in outpatients with chronic liver disease: a cross-sectional study BMC Gastroenterology Chronic liver disease Health-related quality of life Depressive symptoms Surveys and Questionnaires Cross-sectional studies |
| title | Health-related quality of life in outpatients with chronic liver disease: a cross-sectional study |
| title_full | Health-related quality of life in outpatients with chronic liver disease: a cross-sectional study |
| title_fullStr | Health-related quality of life in outpatients with chronic liver disease: a cross-sectional study |
| title_full_unstemmed | Health-related quality of life in outpatients with chronic liver disease: a cross-sectional study |
| title_short | Health-related quality of life in outpatients with chronic liver disease: a cross-sectional study |
| title_sort | health related quality of life in outpatients with chronic liver disease a cross sectional study |
| topic | Chronic liver disease Health-related quality of life Depressive symptoms Surveys and Questionnaires Cross-sectional studies |
| url | https://doi.org/10.1186/s12876-021-01890-7 |
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