Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients
Introduction: Complex integrated information on disease mechanisms and in-hospital outcomes in mild to moderate acute kidney injury (AKI) is scarce. Methods: The Stockholm Prospective AKI Cohort Study (SAKIS) included all patients (≥18 years, n = 1,519) with community-acquired AKI (KDIGO criteria) a...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-11-01
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| Series: | Kidney Diseases |
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| Online Access: | https://www.karger.com/Article/FullText/527299 |
| _version_ | 1797979267649241088 |
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| author | Christina Montgomerie Jonas Spaak Marie Evans Stefan H. Jacobson |
| author_facet | Christina Montgomerie Jonas Spaak Marie Evans Stefan H. Jacobson |
| author_sort | Christina Montgomerie |
| collection | DOAJ |
| description | Introduction: Complex integrated information on disease mechanisms and in-hospital outcomes in mild to moderate acute kidney injury (AKI) is scarce. Methods: The Stockholm Prospective AKI Cohort Study (SAKIS) included all patients (≥18 years, n = 1,519) with community-acquired AKI (KDIGO criteria) admitted to the nephrology ward at Danderyd University Hospital, Stockholm, Sweden, between 2009 and 2018. Detailed laboratory measures were registered. Odds ratio for hypo- and hyperkalemia, recovery of kidney function by 30% and 50%, and in-hospital mortality were assessed by logistic regression analysis. Results: Factors independently associated with the presence of hyperkalemia at admission were high age, high serum creatinine (sCr), and low C-reactive protein (CRP). Signs of malnutrition, inflammation, and acidosis were seen in 31% of patients. Kidney recovery, defined as a reduction of sCr by 30% in-hospital (63% of all patients), was associated with higher age, female sex, lower body mass index (BMI), higher hemoglobin, and higher CRP. Factors independently associated with mortality (4.4% of patients) were high age, high BMI, and low albumin. Conclusion: This study provides a detailed description of community-acquired AKI and comprehensive analyses of integrated clinical and laboratory data associated with kidney recovery. Features related to anemia, albuminuria, malnutrition, inflammation, and acidosis associate with partial or moderate short-term recovery of kidney function, with disturbances in potassium homeostasis, and with in-hospital mortality. Future studies are warranted to analyze the long-term consequences of AKI in terms of risk of kidney failure, cardiovascular morbidity, and mortality. |
| first_indexed | 2024-04-11T05:36:14Z |
| format | Article |
| id | doaj.art-c90c7753ae5f40e7a8291bd54f6edb92 |
| institution | Directory Open Access Journal |
| issn | 2296-9381 2296-9357 |
| language | English |
| last_indexed | 2024-04-11T05:36:14Z |
| publishDate | 2022-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney Diseases |
| spelling | doaj.art-c90c7753ae5f40e7a8291bd54f6edb922022-12-22T12:25:03ZengKarger PublishersKidney Diseases2296-93812296-93572022-11-0111010.1159/000527299527299Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 PatientsChristina Montgomerie0https://orcid.org/0000-0001-7838-2342Jonas Spaak1https://orcid.org/0000-0002-2135-1294Marie Evans2Stefan H. Jacobson3Division of Nephrology, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, SwedenDivision of Cardiology, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, SwedenDepartment of Renal Medicine, CLINTEC, Karolinska Institutet, Karolinska University Hospital, Stockholm, SwedenDivision of Nephrology, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, SwedenIntroduction: Complex integrated information on disease mechanisms and in-hospital outcomes in mild to moderate acute kidney injury (AKI) is scarce. Methods: The Stockholm Prospective AKI Cohort Study (SAKIS) included all patients (≥18 years, n = 1,519) with community-acquired AKI (KDIGO criteria) admitted to the nephrology ward at Danderyd University Hospital, Stockholm, Sweden, between 2009 and 2018. Detailed laboratory measures were registered. Odds ratio for hypo- and hyperkalemia, recovery of kidney function by 30% and 50%, and in-hospital mortality were assessed by logistic regression analysis. Results: Factors independently associated with the presence of hyperkalemia at admission were high age, high serum creatinine (sCr), and low C-reactive protein (CRP). Signs of malnutrition, inflammation, and acidosis were seen in 31% of patients. Kidney recovery, defined as a reduction of sCr by 30% in-hospital (63% of all patients), was associated with higher age, female sex, lower body mass index (BMI), higher hemoglobin, and higher CRP. Factors independently associated with mortality (4.4% of patients) were high age, high BMI, and low albumin. Conclusion: This study provides a detailed description of community-acquired AKI and comprehensive analyses of integrated clinical and laboratory data associated with kidney recovery. Features related to anemia, albuminuria, malnutrition, inflammation, and acidosis associate with partial or moderate short-term recovery of kidney function, with disturbances in potassium homeostasis, and with in-hospital mortality. Future studies are warranted to analyze the long-term consequences of AKI in terms of risk of kidney failure, cardiovascular morbidity, and mortality.https://www.karger.com/Article/FullText/527299acute kidney injuryhyperkalemiahypokalemiainflammationmalnutritionchronic kidney diseasekidney recovery |
| spellingShingle | Christina Montgomerie Jonas Spaak Marie Evans Stefan H. Jacobson Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients Kidney Diseases acute kidney injury hyperkalemia hypokalemia inflammation malnutrition chronic kidney disease kidney recovery |
| title | Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients |
| title_full | Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients |
| title_fullStr | Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients |
| title_full_unstemmed | Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients |
| title_short | Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients |
| title_sort | acute kidney injury clinical characteristics and short term outcomes in 1 519 patients |
| topic | acute kidney injury hyperkalemia hypokalemia inflammation malnutrition chronic kidney disease kidney recovery |
| url | https://www.karger.com/Article/FullText/527299 |
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