The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study
Objective. We examined whether or not day-to-day variations in lipid profiles, especially triglyceride (TG) variability, were associated with the exacerbation of diabetic kidney disease. Methods. We conducted a retrospective and observational study. First, 527 patients with type 2 diabetes mellitus...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2022-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/3157841 |
| _version_ | 1826998463374557184 |
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| author | Natsumi Matsuoka-Uchiyama Haruhito A. Uchida Shugo Okamoto Yasuhiro Onishi Katsuyoshi Katayama Mariko Tsuchida-Nishiwaki Hidemi Takeuchi Rika Takemoto Yoshiko Hada Ryoko Umebayashi Naoko Kurooka Kenji Tsuji Jun Eguchi Hirofumi Nakajima Kenichi Shikata Jun Wada |
| author_facet | Natsumi Matsuoka-Uchiyama Haruhito A. Uchida Shugo Okamoto Yasuhiro Onishi Katsuyoshi Katayama Mariko Tsuchida-Nishiwaki Hidemi Takeuchi Rika Takemoto Yoshiko Hada Ryoko Umebayashi Naoko Kurooka Kenji Tsuji Jun Eguchi Hirofumi Nakajima Kenichi Shikata Jun Wada |
| author_sort | Natsumi Matsuoka-Uchiyama |
| collection | DOAJ |
| description | Objective. We examined whether or not day-to-day variations in lipid profiles, especially triglyceride (TG) variability, were associated with the exacerbation of diabetic kidney disease. Methods. We conducted a retrospective and observational study. First, 527 patients with type 2 diabetes mellitus (DM) who had had their estimated glomerular filtration rate (eGFR) checked every 6 months since 2012 for over 5 years were registered. Variability in postprandial TG was determined using the standard deviation (SD), SD adjusted (Adj-SD) for the number of measurements, and maximum minus minimum difference (MMD) during the first three years of follow-up. The endpoint was a ≥40% decline from baseline in the eGFR, initiation of dialysis or death. Next, 181 patients who had no micro- or macroalbuminuria in February 2013 were selected from among the 527 patients for an analysis. The endpoint was the incidence of microalbuminuria, initiation of dialysis, or death. Results. Among the 527 participants, 110 reached a ≥40% decline from baseline in the eGFR or death. The renal survival was lower in the higher-SD, higher-Adj-SD, and higher-MMD groups than in the lower-SD, lower-Adj-SD, and lower-MMD groups, respectively (log-rank test p=0.0073, 0.0059, and 0.0195, respectively). A lower SD, lower Adj-SD, and lower MMD were significantly associated with the renal survival in the adjusted model (hazard ratio, 1.62, 1.66, 1.59; 95% confidence intervals, 1.05-2.53, 1.08-2.58, 1.04-2.47, respectively). Next, among 181 participants, 108 developed microalbuminuria or death. The nonincidence of microalbuminuria was lower in the higher-SD, higher-Adj-SD, and higher-MMD groups than in the lower-SD, lower-Adj-SD, and lower-MMD groups, respectively (log-rank test p=0.0241, 0.0352, and 0.0474, respectively). Conclusions. Postprandial TG variability is a novel risk factor for eGFR decline and the incidence of microalbuminuria in patients with type 2 DM. |
| first_indexed | 2024-04-11T18:13:11Z |
| format | Article |
| id | doaj.art-c90d294acb554d4081c2a0f50361f65d |
| institution | Directory Open Access Journal |
| issn | 2314-6753 |
| language | English |
| last_indexed | 2025-02-18T10:14:42Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj.art-c90d294acb554d4081c2a0f50361f65d2024-11-02T05:32:32ZengHindawi LimitedJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/3157841The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational StudyNatsumi Matsuoka-Uchiyama0Haruhito A. Uchida1Shugo Okamoto2Yasuhiro Onishi3Katsuyoshi Katayama4Mariko Tsuchida-Nishiwaki5Hidemi Takeuchi6Rika Takemoto7Yoshiko Hada8Ryoko Umebayashi9Naoko Kurooka10Kenji Tsuji11Jun Eguchi12Hirofumi Nakajima13Kenichi Shikata14Jun Wada15Department of NephrologyDepartment of Chronic Kidney Disease and Cardiovascular DiseaseDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyNakashima HospitalCenter for Innovative Clinical MedicineDepartment of NephrologyObjective. We examined whether or not day-to-day variations in lipid profiles, especially triglyceride (TG) variability, were associated with the exacerbation of diabetic kidney disease. Methods. We conducted a retrospective and observational study. First, 527 patients with type 2 diabetes mellitus (DM) who had had their estimated glomerular filtration rate (eGFR) checked every 6 months since 2012 for over 5 years were registered. Variability in postprandial TG was determined using the standard deviation (SD), SD adjusted (Adj-SD) for the number of measurements, and maximum minus minimum difference (MMD) during the first three years of follow-up. The endpoint was a ≥40% decline from baseline in the eGFR, initiation of dialysis or death. Next, 181 patients who had no micro- or macroalbuminuria in February 2013 were selected from among the 527 patients for an analysis. The endpoint was the incidence of microalbuminuria, initiation of dialysis, or death. Results. Among the 527 participants, 110 reached a ≥40% decline from baseline in the eGFR or death. The renal survival was lower in the higher-SD, higher-Adj-SD, and higher-MMD groups than in the lower-SD, lower-Adj-SD, and lower-MMD groups, respectively (log-rank test p=0.0073, 0.0059, and 0.0195, respectively). A lower SD, lower Adj-SD, and lower MMD were significantly associated with the renal survival in the adjusted model (hazard ratio, 1.62, 1.66, 1.59; 95% confidence intervals, 1.05-2.53, 1.08-2.58, 1.04-2.47, respectively). Next, among 181 participants, 108 developed microalbuminuria or death. The nonincidence of microalbuminuria was lower in the higher-SD, higher-Adj-SD, and higher-MMD groups than in the lower-SD, lower-Adj-SD, and lower-MMD groups, respectively (log-rank test p=0.0241, 0.0352, and 0.0474, respectively). Conclusions. Postprandial TG variability is a novel risk factor for eGFR decline and the incidence of microalbuminuria in patients with type 2 DM.http://dx.doi.org/10.1155/2022/3157841 |
| spellingShingle | Natsumi Matsuoka-Uchiyama Haruhito A. Uchida Shugo Okamoto Yasuhiro Onishi Katsuyoshi Katayama Mariko Tsuchida-Nishiwaki Hidemi Takeuchi Rika Takemoto Yoshiko Hada Ryoko Umebayashi Naoko Kurooka Kenji Tsuji Jun Eguchi Hirofumi Nakajima Kenichi Shikata Jun Wada The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study Journal of Diabetes Research |
| title | The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study |
| title_full | The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study |
| title_fullStr | The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study |
| title_full_unstemmed | The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study |
| title_short | The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study |
| title_sort | association of postprandial triglyceride variability with renal dysfunction and microalbuminuria in patients with type 2 diabetic mellitus a retrospective and observational study |
| url | http://dx.doi.org/10.1155/2022/3157841 |
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