Insights into Sickle Cell Disease through the Retinal Microvasculature

Insights into Sickle Cell Disease through the Retinal Microvasculature

Purpose: Clinical OCT angiography (OCTA) of the retinal microvasculature offers a quantitative correlate to systemic disease burden and treatment efficacy in sickle cell disease (SCD). The purpose of this study was to use the higher resolution of adaptive optics scanning light ophthalmoscopy (AOSLO)...

Full description

Bibliographic Details
Main Authors:	Alexander Pinhas, MD, Justin V. Migacz, PhD, Davis B. Zhou, MD, Maria V. Castanos Toral, MD, Oscar Otero-Marquez, MD, Sharon Israel, BA, Vincent Sun, MD, Peter N. Gillette, MD, Nripun Sredar, PhD, Alfredo Dubra, PhD, Jeffrey Glassberg, MD, Richard B. Rosen, MD, Toco Y.P. Chui, PhD
Format:	Article
Language:	English
Published:	Elsevier 2022-12-01
Series:	Ophthalmology Science
Subjects:	Adaptive optics OCT angiography Oculomics Retinal microvasculature Sickle cell disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666914522000859

Similar Items

The Relationship Between Artificial Intelligence–Assisted OCT Angiography–Derived Foveal Avascular Zone Parameters and Visual-Field Defect Progression in Eyes with Open-Angle Glaucoma
by: Takahiro Ninomiya, MD, et al.
Published: (2024-03-01)

Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases
by: Mattia Tomasoni, PhD, et al.
Published: (2023-09-01)

Sickle cell anemia with perforated duodenal ulcer as a complication: when to suspect this rare entity?
by: Raquel Nascimento Lopes, MD, et al.
Published: (2021-10-01)

A Joint Multitask Learning Model for Cross-sectional and Longitudinal Predictions of Visual Field Using OCT
by: Ryo Asaoka, MD, PhD, et al.
Published: (2021-12-01)

Federated Learning for Microvasculature Segmentation and Diabetic Retinopathy Classification of OCT Data
by: Julian Lo, MASc, et al.
Published: (2021-12-01)

Comparison of Microperimetry and Static Perimetry for Evaluating Macular Function and Progression in Retinitis Pigmentosa
by: Masatoshi Fukushima, MD, et al.
Published: (2024-11-01)

The Association of Sickle-Cell Disorders With Diabetic Retinopathy: A Large Database Study
by: Muhammad Z. Chauhan, MD, MS, et al.
Published: (2024-07-01)

Distribution of Choroidal Thickness and Choroidal Vessel Dilation in Healthy Japanese Individuals
by: Yuki Mori, MD, et al.
Published: (2021-06-01)

Hemoglobinopathy is Associated With Total Hip Arthroplasty Indication Even Beyond Sickle Cell Anemia
by: Maxwell J. Rakutt, BS, et al.
Published: (2023-02-01)

Association Between Choroidal Thickness and Myopic Maculopathy in a Japanese Population
by: Emi Ueda, MD, PhD, et al.
Published: (2023-12-01)

Challenges of Engaging Primary Care Providers in Specialized Telementoring Education About Sickle Cell Disease for Sickle Cell Specialists: Results from the Sickle Cell Disease Training and Mentoring Program for Primary Care Providers (STAMP) Project ECHO
by: Lisa M. Shook, DHPE, MA, MCHES, et al.
Published: (2025-02-01)

Assessment of Retinal Volume in Individuals Without Ocular Disorders Based on Wide-Field Swept-Source OCT
by: Yoshiaki Chiku, MD, et al.
Published: (2024-11-01)

Fat emboli and critical illness-associated cerebral microbleeds (CICMs) in a patient with sickle cell disease: Do these 2 entities coexist?
by: Selsabil Mohammed-Hadj, MD, et al.
Published: (2023-05-01)

The Caliber of Optociliary Shunt Vessels Is Associated with Macular Blood Flow and Visual Acuity in Central Retinal Vein Occlusion
by: Masanori Kanai, MD, et al.
Published: (2022-03-01)

Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery
by: Matteo Giuseppe Cereda, MD, et al.
Published: (2021-12-01)

Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice
by: David O. Osei-Hwedieh, PhD, et al.
Published: (2016-09-01)

Characteristics of Emergency Department Visits Made by Individuals With Sickle Cell Disease in the U.S., 1999–2020
by: Brandon K. Attell, PhD, et al.
Published: (2024-02-01)

Screening for pulmonary hypertension in pregnant women with sickle cell disease in sub-Saharan AfricaAJOG Global Reports at a Glance
by: Alim Swarray-Deen, MD, et al.
Published: (2024-11-01)

Epiretinal Membrane Impairs the Inner Retinal Layer in a Traction Force-Dependent Manner
by: Yuki Kanzaki, MD, PhD, et al.
Published: (2023-09-01)

Improving Interpretability in Machine Diagnosis
by: Xiaoshuang Shi, PhD, et al.
Published: (2021-09-01)

Risk Factors for Focal Choroidal Excavation Concurrent with Chorioretinal Disease: Evaluated by Spectral-Domain OCT
by: Yiwen Ou, MD, et al.
Published: (2024-11-01)

Clinically Significant Nonperfusion Areas on Widefield OCT Angiography in Diabetic Retinopathy
by: Kentaro Kawai, MD, et al.
Published: (2023-03-01)

Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity
by: Brittni A. Scruggs, MD, PhD, et al.
Published: (2022-03-01)

In Vivo Visualization and Quantification of Optic Disc Microvasculature for Assessing Renal Dysfunction
by: Xiao Guo, MD, et al.
Published: (2024-01-01)

Preimplantation genetic testing for sickle cell disease: a cost-effectiveness analysis
by: Joshua C. Combs, M.D., et al.
Published: (2023-09-01)

Quantitative Parameters from OCT Angiography in Patients with Diabetic Retinopathy and in Those with Only Peripheral Retinopathy Compared with Control Participants
by: Ruth E. Hogg, PhD, et al.
Published: (2021-06-01)

Deep-GA-Net for Accurate and Explainable Detection of Geographic Atrophy on OCT Scans
by: Amr Elsawy, PhD, et al.
Published: (2023-12-01)

Total Hip Arthroplasty Complications in Patients With Sickle Cell Disease: A Comparison Study
by: Christian DeMaio, BS, et al.
Published: (2024-12-01)

Hemoglobin and End-Organ Damage in Individuals with Sickle Cell Disease
by: William B. Ershler, MD, et al.
Published: (2023-01-01)

Quantitative Mapping of Posterior Eye Curvature in Children Using Distortion-Corrected OCT: Insights into Temporal Region Morphology
by: Takahiro Hiraoka, MD, PhD, et al.
Published: (2025-05-01)

Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular Degeneration
by: Gissel Herrera, MD, et al.
Published: (2025-03-01)

Vitrectomy in Diabetic Macular Edema
by: Zofia Anna Nawrocka, MD, PhD, et al.
Published: (2022-12-01)

Detection of Nonexudative Macular Neovascularization on Structural OCT Images Using Vision Transformers
by: Yuka Kihara, MS, et al.
Published: (2022-12-01)

Deep-Reticular Pseudodrusen-Net: A 3-Dimensional Deep Network for Detection of Reticular Pseudodrusen on OCT Scans
by: Amr Elsawy, PhD, et al.
Published: (2025-03-01)

Reduced Cone Density Is Associated with Multiple Sclerosis
by: Gemma McIlwaine, MSc, et al.
Published: (2023-09-01)

Assessing Surface Shapes of the Optic Nerve Head and Peripapillary Retinal Nerve Fiber Layer in Glaucoma with Artificial Intelligence
by: Chhavi Saini, MD, et al.
Published: (2022-09-01)

Spectral-Domain and Swept-Source OCT Angiographic Scans Yield Similar Drusen Measurements When Processed with the Same Algorithm
by: Farhan E. Hiya, MD, et al.
Published: (2024-05-01)

Perivenular Capillary Rarefaction in Diabetic Retinopathy
by: Emanuele Crincoli, MD, et al.
Published: (2023-06-01)

Deep-Learning–Aided Diagnosis of Diabetic Retinopathy, Age-Related Macular Degeneration, and Glaucoma Based on Structural and Angiographic OCT
by: Pengxiao Zang, MS, et al.
Published: (2023-03-01)

SURVIVAL PROBABILITY IN PATIENTS WITH SICKLE CELL ANEMIA USING THE COMPETITIVE RISK STATISTICAL MODEL
by: Samir Ballas, et al.
Published: (2019-02-01)