Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases
Introduction: De Quervain’s Thyroiditis (DQT) is a self limiting inflammatory disease of the thyroid gland that presents with pain and sore throat. Although the diagnosis is usually made clinically, Fine Needle Aspiration (FNA) may provide assistance, particularly in excluding other thyroid lesi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10355/26054_CE[Ra]_F(Sh)PF1_(RB_KM_PY)_PFA(RB_SY_GG)_PF2(SS).pdf |
| Summary: | Introduction: De Quervain’s Thyroiditis (DQT) is a self limiting
inflammatory disease of the thyroid gland that presents with
pain and sore throat. Although the diagnosis is usually made
clinically, Fine Needle Aspiration (FNA) may provide assistance,
particularly in excluding other thyroid lesions.
Aim: The objective of this study was to reveal the cytological
characteristics of DQT.
Materials and Methods: We retrospectively reviewed the
clinical and FNAC findings of 20 cases of DQT to find the most
reliable features for a confident cytological diagnosis.
Results: Among the cases reviewed, the common cytological
features present in all 20 cases were follicular epithelial cells
with degenerative changes and dirty background comprising of
cellular debris and mixed inflammatory cells (lymphocytes and
macrophages and occasional polymorphs). The next common
finding observed was Multinucleated Giant Cells (MNGCs) seen
in 19 cases followed by epithelioid cell clusters in 15 and colloid
in 13 cases.
Conclusion: Presence of follicular epithelial cells, large MNGCs
and dirty background of cellular debris, mixed inflammatory
cells with predominance of lymphocytes and macrophages were
the most striking and consistent features for diagnosis of DQT
in cytological smears. The above findings in consideration with
the clinical history will help us to reach a definitive diagnosis.
FNA also proves to be a useful tool in excluding other thyroid
lesions with similar clinical presentations. |
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| ISSN: | 2249-782X 0973-709X |