Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases
Introduction: De Quervain’s Thyroiditis (DQT) is a self limiting inflammatory disease of the thyroid gland that presents with pain and sore throat. Although the diagnosis is usually made clinically, Fine Needle Aspiration (FNA) may provide assistance, particularly in excluding other thyroid lesi...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/10355/26054_CE[Ra]_F(Sh)PF1_(RB_KM_PY)_PFA(RB_SY_GG)_PF2(SS).pdf |
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| author | Rachna Lamichaney Mingma Sherpa Deepak Das Chumila Thinley Bhutia Sabina Laishram |
| author_facet | Rachna Lamichaney Mingma Sherpa Deepak Das Chumila Thinley Bhutia Sabina Laishram |
| author_sort | Rachna Lamichaney |
| collection | DOAJ |
| description | Introduction: De Quervain’s Thyroiditis (DQT) is a self limiting
inflammatory disease of the thyroid gland that presents with
pain and sore throat. Although the diagnosis is usually made
clinically, Fine Needle Aspiration (FNA) may provide assistance,
particularly in excluding other thyroid lesions.
Aim: The objective of this study was to reveal the cytological
characteristics of DQT.
Materials and Methods: We retrospectively reviewed the
clinical and FNAC findings of 20 cases of DQT to find the most
reliable features for a confident cytological diagnosis.
Results: Among the cases reviewed, the common cytological
features present in all 20 cases were follicular epithelial cells
with degenerative changes and dirty background comprising of
cellular debris and mixed inflammatory cells (lymphocytes and
macrophages and occasional polymorphs). The next common
finding observed was Multinucleated Giant Cells (MNGCs) seen
in 19 cases followed by epithelioid cell clusters in 15 and colloid
in 13 cases.
Conclusion: Presence of follicular epithelial cells, large MNGCs
and dirty background of cellular debris, mixed inflammatory
cells with predominance of lymphocytes and macrophages were
the most striking and consistent features for diagnosis of DQT
in cytological smears. The above findings in consideration with
the clinical history will help us to reach a definitive diagnosis.
FNA also proves to be a useful tool in excluding other thyroid
lesions with similar clinical presentations. |
| first_indexed | 2024-12-14T19:43:47Z |
| format | Article |
| id | doaj.art-c90ef7b3642d43119047742fbfd026a6 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T19:43:47Z |
| publishDate | 2017-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-c90ef7b3642d43119047742fbfd026a62022-12-21T22:49:38ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-08-01118EC09EC1110.7860/JCDR/2017/26054.10355Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 CasesRachna Lamichaney0Mingma Sherpa1Deepak Das2Chumila Thinley Bhutia3Sabina Laishram4Assistant professor, Department of Pathology, SMIMS, Gangtok, Sikkim, India.Associate professor, Department of Pathology, SMIMS, Gangtok, Sikkim, India.Demonstrator, Department of Pathology, Jorhat Medical College, Jorhat, Assam, India.Assistant Professor, Department of Pathology, SMIMS, Gangtok, Sikkim, India.Assistant Professor, Department of Pathology, SMIMS, Gangtok, Sikkim, India.Introduction: De Quervain’s Thyroiditis (DQT) is a self limiting inflammatory disease of the thyroid gland that presents with pain and sore throat. Although the diagnosis is usually made clinically, Fine Needle Aspiration (FNA) may provide assistance, particularly in excluding other thyroid lesions. Aim: The objective of this study was to reveal the cytological characteristics of DQT. Materials and Methods: We retrospectively reviewed the clinical and FNAC findings of 20 cases of DQT to find the most reliable features for a confident cytological diagnosis. Results: Among the cases reviewed, the common cytological features present in all 20 cases were follicular epithelial cells with degenerative changes and dirty background comprising of cellular debris and mixed inflammatory cells (lymphocytes and macrophages and occasional polymorphs). The next common finding observed was Multinucleated Giant Cells (MNGCs) seen in 19 cases followed by epithelioid cell clusters in 15 and colloid in 13 cases. Conclusion: Presence of follicular epithelial cells, large MNGCs and dirty background of cellular debris, mixed inflammatory cells with predominance of lymphocytes and macrophages were the most striking and consistent features for diagnosis of DQT in cytological smears. The above findings in consideration with the clinical history will help us to reach a definitive diagnosis. FNA also proves to be a useful tool in excluding other thyroid lesions with similar clinical presentations.https://jcdr.net/articles/PDF/10355/26054_CE[Ra]_F(Sh)PF1_(RB_KM_PY)_PFA(RB_SY_GG)_PF2(SS).pdfcytologydegenerated follicular epithelial cellsmultinucleated giant cells |
| spellingShingle | Rachna Lamichaney Mingma Sherpa Deepak Das Chumila Thinley Bhutia Sabina Laishram Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases Journal of Clinical and Diagnostic Research cytology degenerated follicular epithelial cells multinucleated giant cells |
| title | Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases |
| title_full | Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases |
| title_fullStr | Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases |
| title_full_unstemmed | Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases |
| title_short | Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases |
| title_sort | fine needle aspiration of de quervain s thyroiditis subacute granulomatous thyroiditis a cytological review of 20 cases |
| topic | cytology degenerated follicular epithelial cells multinucleated giant cells |
| url | https://jcdr.net/articles/PDF/10355/26054_CE[Ra]_F(Sh)PF1_(RB_KM_PY)_PFA(RB_SY_GG)_PF2(SS).pdf |
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