The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD
Abstract Airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is an amplified response of the normal immune system that occurs as a result of chronic irritation by toxic substances, such as cigarette smoke. This leads to the characteristic pathological changes in the inf...
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| Format: | Article |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-02615-2 |
| _version_ | 1831583407327412224 |
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| author | Muhammad Fachri Mochammad Hatta Muhammad Nasrum Massi Arif Santoso Tri Ariguntar Wikanningtyas Ressy Dwiyanti Ade Rifka Junita Muhammad Reza Primaguna Muhammad Sabir |
| author_facet | Muhammad Fachri Mochammad Hatta Muhammad Nasrum Massi Arif Santoso Tri Ariguntar Wikanningtyas Ressy Dwiyanti Ade Rifka Junita Muhammad Reza Primaguna Muhammad Sabir |
| author_sort | Muhammad Fachri |
| collection | DOAJ |
| description | Abstract Airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is an amplified response of the normal immune system that occurs as a result of chronic irritation by toxic substances, such as cigarette smoke. This leads to the characteristic pathological changes in the inflammatory cells of COPD patients. ADAM33 has been reported to be involved in the pathogenesis of COPD in East Asia by affecting airway inflammation and other immune responses. The aim of this study was to determine the potential role of ADAM33 (mRNA and soluble levels) as a biomarker of inflammation in COPD patients. This is a case control study using consecutive sampling. The COPD case and control (non-COPD) groups comprised 37 and 29 patients, respectively. We used univariate analysis to assess differences in the parameters between the groups and bivariate analysis to non-parametrically compare these parameters between the two groups. We observed significantly higher mRNA levels of ADAM33 in the COPD patients (10.39 ± 1.76) as compared to that in the non-COPD individuals (6.93 ± 0.39; P < 0.001). The levels of soluble ADAM33 were also significantly higher in the COPD patients (2.188 ± 1.142 ng/ml) compared to the non-COPD individuals (0.487 ± 0.105 ng/ml; P < 0.001). The mRNA and soluble ADAM33 levels were significantly higher in COPD patients compared to those in the parameter-matched non-COPD individuals. Thus, ADAM33 is a potential biomarker and treatment for inflammation in COPD patients. |
| first_indexed | 2024-12-17T20:41:41Z |
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| id | doaj.art-c90f9b35e93d4471aa2fb0e17ab076d8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T20:41:41Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-c90f9b35e93d4471aa2fb0e17ab076d82022-12-21T21:33:17ZengNature PortfolioScientific Reports2045-23222021-11-0111111310.1038/s41598-021-02615-2The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPDMuhammad Fachri0Mochammad Hatta1Muhammad Nasrum Massi2Arif Santoso3Tri Ariguntar Wikanningtyas4Ressy Dwiyanti5Ade Rifka Junita6Muhammad Reza Primaguna7Muhammad Sabir8Department of Pulmonology and Respiratory Medicine, Faculty of Medicine and Health, Universitas MuhammadiyahMolecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin UniversityMolecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin UniversityDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin UniversityDepartment of Clinical Pathology, Faculty of Medicine and Health, Universitas MuhammadiyahMolecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin UniversityMolecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin UniversityDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin UniversityDepartment of Medical Microbiology, Faculty of Medicine, Tadulako UniversityAbstract Airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is an amplified response of the normal immune system that occurs as a result of chronic irritation by toxic substances, such as cigarette smoke. This leads to the characteristic pathological changes in the inflammatory cells of COPD patients. ADAM33 has been reported to be involved in the pathogenesis of COPD in East Asia by affecting airway inflammation and other immune responses. The aim of this study was to determine the potential role of ADAM33 (mRNA and soluble levels) as a biomarker of inflammation in COPD patients. This is a case control study using consecutive sampling. The COPD case and control (non-COPD) groups comprised 37 and 29 patients, respectively. We used univariate analysis to assess differences in the parameters between the groups and bivariate analysis to non-parametrically compare these parameters between the two groups. We observed significantly higher mRNA levels of ADAM33 in the COPD patients (10.39 ± 1.76) as compared to that in the non-COPD individuals (6.93 ± 0.39; P < 0.001). The levels of soluble ADAM33 were also significantly higher in the COPD patients (2.188 ± 1.142 ng/ml) compared to the non-COPD individuals (0.487 ± 0.105 ng/ml; P < 0.001). The mRNA and soluble ADAM33 levels were significantly higher in COPD patients compared to those in the parameter-matched non-COPD individuals. Thus, ADAM33 is a potential biomarker and treatment for inflammation in COPD patients.https://doi.org/10.1038/s41598-021-02615-2 |
| spellingShingle | Muhammad Fachri Mochammad Hatta Muhammad Nasrum Massi Arif Santoso Tri Ariguntar Wikanningtyas Ressy Dwiyanti Ade Rifka Junita Muhammad Reza Primaguna Muhammad Sabir The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD Scientific Reports |
| title | The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD |
| title_full | The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD |
| title_fullStr | The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD |
| title_full_unstemmed | The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD |
| title_short | The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD |
| title_sort | strong correlation between adam33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of copd |
| url | https://doi.org/10.1038/s41598-021-02615-2 |
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