“One Health” perspective on prevalence of co-existing extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae: a comprehensive systematic review and meta-analysis
Abstract Background The Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) bacterial isolates that produce extended-spectrum β-lactamases (ESBLs) contribute to global life-threatening infections. This study conducted a systematic review and meta-analysis on the global prevalence of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12941-023-00638-3 |
| _version_ | 1797453634910289920 |
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| author | Tsepo Ramatla Tshepo Mafokwane Kgaugelo Lekota Maropeng Monyama George Khasapane Naledi Serage Jane Nkhebenyane Carlos Bezuidenhout Oriel Thekisoe |
| author_facet | Tsepo Ramatla Tshepo Mafokwane Kgaugelo Lekota Maropeng Monyama George Khasapane Naledi Serage Jane Nkhebenyane Carlos Bezuidenhout Oriel Thekisoe |
| author_sort | Tsepo Ramatla |
| collection | DOAJ |
| description | Abstract Background The Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) bacterial isolates that produce extended-spectrum β-lactamases (ESBLs) contribute to global life-threatening infections. This study conducted a systematic review and meta-analysis on the global prevalence of ESBLs in co-existing E. coli and K. pneumoniae isolated from humans, animals and the environment. Methods The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) [ID no: CRD42023394360]. This study was carried out following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. One hundred and twenty-six eligible studies published on co-existing antibiotic resistance in E. coli and K. pneumoniae between 1990 and 2022 were included. Results The pooled prevalence of ESBL-producing E. coli and K. pneumoniae was 33.0% and 32.7% for humans, 33.5% and 19.4% for animals, 56.9% and 24.2% for environment, 26.8% and 6.7% for animals/environment, respectively. Furthermore, the three types of resistance genes that encode ESBLs, namely bla SHV bla CTX−M ,bla OXA , and bla TEM , were all detected in humans, animals and the environment. Conclusions The concept of “One-Health” surveillance is critical to tracking the source of antimicrobial resistance and preventing its spread. The emerging state and national surveillance systems should include bacteria containing ESBLs. A well-planned, -implemented, and -researched alternative treatment for antimicrobial drug resistance needs to be formulated. |
| first_indexed | 2024-03-09T15:25:40Z |
| format | Article |
| id | doaj.art-c9105091a93b464a91eb680bca38808e |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-03-09T15:25:40Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-c9105091a93b464a91eb680bca38808e2023-11-26T12:34:40ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112023-09-0122111710.1186/s12941-023-00638-3“One Health” perspective on prevalence of co-existing extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae: a comprehensive systematic review and meta-analysisTsepo Ramatla0Tshepo Mafokwane1Kgaugelo Lekota2Maropeng Monyama3George Khasapane4Naledi Serage5Jane Nkhebenyane6Carlos Bezuidenhout7Oriel Thekisoe8Unit for Environmental Sciences and Management, North-West UniversityDepartment of Life and Consumer Sciences, University of South AfricaUnit for Environmental Sciences and Management, North-West UniversityDepartment of Life and Consumer Sciences, University of South AfricaDepartment of Life Sciences, Central University of TechnologyUnit for Environmental Sciences and Management, North-West UniversityDepartment of Life Sciences, Central University of TechnologyUnit for Environmental Sciences and Management, North-West UniversityUnit for Environmental Sciences and Management, North-West UniversityAbstract Background The Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) bacterial isolates that produce extended-spectrum β-lactamases (ESBLs) contribute to global life-threatening infections. This study conducted a systematic review and meta-analysis on the global prevalence of ESBLs in co-existing E. coli and K. pneumoniae isolated from humans, animals and the environment. Methods The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) [ID no: CRD42023394360]. This study was carried out following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. One hundred and twenty-six eligible studies published on co-existing antibiotic resistance in E. coli and K. pneumoniae between 1990 and 2022 were included. Results The pooled prevalence of ESBL-producing E. coli and K. pneumoniae was 33.0% and 32.7% for humans, 33.5% and 19.4% for animals, 56.9% and 24.2% for environment, 26.8% and 6.7% for animals/environment, respectively. Furthermore, the three types of resistance genes that encode ESBLs, namely bla SHV bla CTX−M ,bla OXA , and bla TEM , were all detected in humans, animals and the environment. Conclusions The concept of “One-Health” surveillance is critical to tracking the source of antimicrobial resistance and preventing its spread. The emerging state and national surveillance systems should include bacteria containing ESBLs. A well-planned, -implemented, and -researched alternative treatment for antimicrobial drug resistance needs to be formulated.https://doi.org/10.1186/s12941-023-00638-3One healthESBLE. coliK. pneumoniaeGlobalmeta-analysis |
| spellingShingle | Tsepo Ramatla Tshepo Mafokwane Kgaugelo Lekota Maropeng Monyama George Khasapane Naledi Serage Jane Nkhebenyane Carlos Bezuidenhout Oriel Thekisoe “One Health” perspective on prevalence of co-existing extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae: a comprehensive systematic review and meta-analysis Annals of Clinical Microbiology and Antimicrobials One health ESBL E. coli K. pneumoniae Global meta-analysis |
| title | “One Health” perspective on prevalence of co-existing extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae: a comprehensive systematic review and meta-analysis |
| title_full | “One Health” perspective on prevalence of co-existing extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae: a comprehensive systematic review and meta-analysis |
| title_fullStr | “One Health” perspective on prevalence of co-existing extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae: a comprehensive systematic review and meta-analysis |
| title_full_unstemmed | “One Health” perspective on prevalence of co-existing extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae: a comprehensive systematic review and meta-analysis |
| title_short | “One Health” perspective on prevalence of co-existing extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae: a comprehensive systematic review and meta-analysis |
| title_sort | one health perspective on prevalence of co existing extended spectrum β lactamase esbl producing escherichia coli and klebsiella pneumoniae a comprehensive systematic review and meta analysis |
| topic | One health ESBL E. coli K. pneumoniae Global meta-analysis |
| url | https://doi.org/10.1186/s12941-023-00638-3 |
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