Effectiveness and safety of Levofloxacin containing regimen in the treatment of Isoniazid mono-resistant pulmonary Tuberculosis: a systematic review
BackgroundWe aimed to determine the effectiveness and safety of the Levofloxacin-containing regimen that the World Health Organization is currently recommending for the treatment of Isoniazid mono-resistant pulmonary Tuberculosis.MethodsOur eligible criteria for the studies to be included were; rand...
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| Format: | Article |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1085010/full |
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| author | Leeberk Raja Inbaraj Hemant Deepak Shewade Jefferson Daniel Vignes Anand Srinivasalu Jabez Paul S. Satish Richard Kirubakaran Chandrasekaran Padmapriyadarsini |
| author_facet | Leeberk Raja Inbaraj Hemant Deepak Shewade Jefferson Daniel Vignes Anand Srinivasalu Jabez Paul S. Satish Richard Kirubakaran Chandrasekaran Padmapriyadarsini |
| author_sort | Leeberk Raja Inbaraj |
| collection | DOAJ |
| description | BackgroundWe aimed to determine the effectiveness and safety of the Levofloxacin-containing regimen that the World Health Organization is currently recommending for the treatment of Isoniazid mono-resistant pulmonary Tuberculosis.MethodsOur eligible criteria for the studies to be included were; randomized controlled trials or cohort studies that focused on adults with Isoniazid mono-resistant tuberculosis (HrTB) and treated with a Levofloxacin-containing regimen along with first-line anti-tubercular drugs; they should have had a control group treated with first-line without Levofloxacin; should have reported treatment success rate, mortality, recurrence, progression to multidrug-resistant Tuberculosis. We performed the search in MEDLINE, EMBASE, Epistemonikos, Google Scholar, and Clinical trials registry. Two authors independently screened the titles/abstracts and full texts that were retained after the initial screening, and a third author resolved disagreements.ResultsOur search found 4,813 records after excluding duplicates. We excluded 4,768 records after screening the titles and abstracts, retaining 44 records. Subsequently, 36 articles were excluded after the full-text screening, and eight appeared to have partially fulfilled the inclusion criteria. We contacted the respective authors, and none responded positively. Hence, no articles were included in the meta-analysis.ConclusionWe found no “quality” evidence currently on the effectiveness and safety of Levofloxacin in treating HrTB.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022290333, identifier: CRD42022290333. |
| first_indexed | 2024-03-13T04:25:14Z |
| format | Article |
| id | doaj.art-c9116d33006543ba998d92afbdf7e14f |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T04:25:14Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-c9116d33006543ba998d92afbdf7e14f2023-06-20T06:33:38ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-06-011010.3389/fmed.2023.10850101085010Effectiveness and safety of Levofloxacin containing regimen in the treatment of Isoniazid mono-resistant pulmonary Tuberculosis: a systematic reviewLeeberk Raja Inbaraj0Hemant Deepak Shewade1Jefferson Daniel2Vignes Anand Srinivasalu3Jabez Paul4S. Satish5Richard Kirubakaran6Chandrasekaran Padmapriyadarsini7Department of Clinical Research, Indian Council of Medical Research-National Institute for Research in Tuberculosis, Chennai, IndiaDivision of Health System Research, Indian Council of Medical Research – National Institute of Epidemiology, Chennai, IndiaDepartment of Pulmonary Medicine, Christian Medical College, Vellore, IndiaDepartment of Clinical Research, Indian Council of Medical Research-National Institute for Research in Tuberculosis, Chennai, IndiaProf. BV Moses Centre for Evidence Informed Healthcare and Health Policy, Christian Medical College, Vellore, IndiaDivision of Health System Research, Indian Council of Medical Research – National Institute of Epidemiology, Chennai, IndiaCenter for Biostastic and Evidence Based Medicine, Vellore, IndiaDepartment of Clinical Research, Indian Council of Medical Research-National Institute for Research in Tuberculosis, Chennai, IndiaBackgroundWe aimed to determine the effectiveness and safety of the Levofloxacin-containing regimen that the World Health Organization is currently recommending for the treatment of Isoniazid mono-resistant pulmonary Tuberculosis.MethodsOur eligible criteria for the studies to be included were; randomized controlled trials or cohort studies that focused on adults with Isoniazid mono-resistant tuberculosis (HrTB) and treated with a Levofloxacin-containing regimen along with first-line anti-tubercular drugs; they should have had a control group treated with first-line without Levofloxacin; should have reported treatment success rate, mortality, recurrence, progression to multidrug-resistant Tuberculosis. We performed the search in MEDLINE, EMBASE, Epistemonikos, Google Scholar, and Clinical trials registry. Two authors independently screened the titles/abstracts and full texts that were retained after the initial screening, and a third author resolved disagreements.ResultsOur search found 4,813 records after excluding duplicates. We excluded 4,768 records after screening the titles and abstracts, retaining 44 records. Subsequently, 36 articles were excluded after the full-text screening, and eight appeared to have partially fulfilled the inclusion criteria. We contacted the respective authors, and none responded positively. Hence, no articles were included in the meta-analysis.ConclusionWe found no “quality” evidence currently on the effectiveness and safety of Levofloxacin in treating HrTB.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022290333, identifier: CRD42022290333.https://www.frontiersin.org/articles/10.3389/fmed.2023.1085010/fullfluoroquinolonesMDR-TBresistant pulmonary TuberculosisIsoniazid resistancelevofloxacin |
| spellingShingle | Leeberk Raja Inbaraj Hemant Deepak Shewade Jefferson Daniel Vignes Anand Srinivasalu Jabez Paul S. Satish Richard Kirubakaran Chandrasekaran Padmapriyadarsini Effectiveness and safety of Levofloxacin containing regimen in the treatment of Isoniazid mono-resistant pulmonary Tuberculosis: a systematic review Frontiers in Medicine fluoroquinolones MDR-TB resistant pulmonary Tuberculosis Isoniazid resistance levofloxacin |
| title | Effectiveness and safety of Levofloxacin containing regimen in the treatment of Isoniazid mono-resistant pulmonary Tuberculosis: a systematic review |
| title_full | Effectiveness and safety of Levofloxacin containing regimen in the treatment of Isoniazid mono-resistant pulmonary Tuberculosis: a systematic review |
| title_fullStr | Effectiveness and safety of Levofloxacin containing regimen in the treatment of Isoniazid mono-resistant pulmonary Tuberculosis: a systematic review |
| title_full_unstemmed | Effectiveness and safety of Levofloxacin containing regimen in the treatment of Isoniazid mono-resistant pulmonary Tuberculosis: a systematic review |
| title_short | Effectiveness and safety of Levofloxacin containing regimen in the treatment of Isoniazid mono-resistant pulmonary Tuberculosis: a systematic review |
| title_sort | effectiveness and safety of levofloxacin containing regimen in the treatment of isoniazid mono resistant pulmonary tuberculosis a systematic review |
| topic | fluoroquinolones MDR-TB resistant pulmonary Tuberculosis Isoniazid resistance levofloxacin |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1085010/full |
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