Gastric Adenocarcinoma with Enteroblastic Differentiation Resected through Endoscopic Submucosal Dissection: A Case Report
Introduction: Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare histological type of gastric adenocarcinoma that occurs in the stomach and is known for its aggressive behavior. GAED is diagnosed histopathologically and is often advanced at the time of diagnosis. Case Present...
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Karger Publishers
2024-02-01
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| Series: | Case Reports in Gastroenterology |
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| Online Access: | https://beta.karger.com/Article/FullText/535954 |
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| author | Akira Ishikawa Koki Nakamura |
| author_facet | Akira Ishikawa Koki Nakamura |
| author_sort | Akira Ishikawa |
| collection | DOAJ |
| description | Introduction: Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare histological type of gastric adenocarcinoma that occurs in the stomach and is known for its aggressive behavior. GAED is diagnosed histopathologically and is often advanced at the time of diagnosis. Case Presentation: We report the case of a 70-year-old male with a 20-mm superficial depressed lesion on the anterior wall of the antrum. Histological examination of the endoscopic submucosal dissection specimen revealed that the tumor was composed of dilated or slit-like branching tubules; additionally, the tumor cells had clear cytoplasm resembling that of the fetal digestive tract. Immunohistochemically, the tumor cells were positive for Glypican-3 and alpha-fetoprotein. A pathological diagnosis of GAEDs was established. GAED was found in approximately 30% of all the tumor cells and showed lymphatic invasion. The patient has been under recurrence-free follow-up for approximately 1 year after the endoscopic submucosal dissection. Conclusion: In order to detect a large number of cases, immunostaining should be aggressively performed if morphological findings are suspicious for GAED. |
| first_indexed | 2024-03-07T19:39:37Z |
| format | Article |
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| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-25T01:57:50Z |
| publishDate | 2024-02-01 |
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| series | Case Reports in Gastroenterology |
| spelling | doaj.art-c912cb4a4e4b4494bf7b83e38351152b2024-03-07T15:41:15ZengKarger PublishersCase Reports in Gastroenterology1662-06312024-02-01181687310.1159/000535954535954Gastric Adenocarcinoma with Enteroblastic Differentiation Resected through Endoscopic Submucosal Dissection: A Case ReportAkira Ishikawa0Koki Nakamura1Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Gastroenterology, Miyoshi Central Hospital, Miyoshi, JapanIntroduction: Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare histological type of gastric adenocarcinoma that occurs in the stomach and is known for its aggressive behavior. GAED is diagnosed histopathologically and is often advanced at the time of diagnosis. Case Presentation: We report the case of a 70-year-old male with a 20-mm superficial depressed lesion on the anterior wall of the antrum. Histological examination of the endoscopic submucosal dissection specimen revealed that the tumor was composed of dilated or slit-like branching tubules; additionally, the tumor cells had clear cytoplasm resembling that of the fetal digestive tract. Immunohistochemically, the tumor cells were positive for Glypican-3 and alpha-fetoprotein. A pathological diagnosis of GAEDs was established. GAED was found in approximately 30% of all the tumor cells and showed lymphatic invasion. The patient has been under recurrence-free follow-up for approximately 1 year after the endoscopic submucosal dissection. Conclusion: In order to detect a large number of cases, immunostaining should be aggressively performed if morphological findings are suspicious for GAED.https://beta.karger.com/Article/FullText/535954gastric canceradenocarcinoma with enteroblastic differentiationhistopathologyimmunohistochemistry |
| spellingShingle | Akira Ishikawa Koki Nakamura Gastric Adenocarcinoma with Enteroblastic Differentiation Resected through Endoscopic Submucosal Dissection: A Case Report Case Reports in Gastroenterology gastric cancer adenocarcinoma with enteroblastic differentiation histopathology immunohistochemistry |
| title | Gastric Adenocarcinoma with Enteroblastic Differentiation Resected through Endoscopic Submucosal Dissection: A Case Report |
| title_full | Gastric Adenocarcinoma with Enteroblastic Differentiation Resected through Endoscopic Submucosal Dissection: A Case Report |
| title_fullStr | Gastric Adenocarcinoma with Enteroblastic Differentiation Resected through Endoscopic Submucosal Dissection: A Case Report |
| title_full_unstemmed | Gastric Adenocarcinoma with Enteroblastic Differentiation Resected through Endoscopic Submucosal Dissection: A Case Report |
| title_short | Gastric Adenocarcinoma with Enteroblastic Differentiation Resected through Endoscopic Submucosal Dissection: A Case Report |
| title_sort | gastric adenocarcinoma with enteroblastic differentiation resected through endoscopic submucosal dissection a case report |
| topic | gastric cancer adenocarcinoma with enteroblastic differentiation histopathology immunohistochemistry |
| url | https://beta.karger.com/Article/FullText/535954 |
| work_keys_str_mv | AT akiraishikawa gastricadenocarcinomawithenteroblasticdifferentiationresectedthroughendoscopicsubmucosaldissectionacasereport AT kokinakamura gastricadenocarcinomawithenteroblasticdifferentiationresectedthroughendoscopicsubmucosaldissectionacasereport |