The unresolved safety concerns of bovine thrombin
<p>Abstract</p> <p>A recent review has suggested that bovine thrombin is not associated with an increased risk of bleeding in surgical populations. In spite of extremely limited evidence available, many valuable resources (e.g. safety surveillance and post-marketing programs, case...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-09-01
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| Series: | Patient Safety in Surgery |
| Online Access: | http://www.pssjournal.com/content/2/1/23 |
| _version_ | 1811251182533869568 |
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| author | Javidroozi Mazyar Shander Aryeh |
| author_facet | Javidroozi Mazyar Shander Aryeh |
| author_sort | Javidroozi Mazyar |
| collection | DOAJ |
| description | <p>Abstract</p> <p>A recent review has suggested that bovine thrombin is not associated with an increased risk of bleeding in surgical populations. In spite of extremely limited evidence available, many valuable resources (e.g. safety surveillance and post-marketing programs, case reports) were excluded in reaching this conclusion. While waiting for the adequately powered, controlled clinical trials to address the effects of bovine thrombin on bleeding and thrombotic events, the potential risk cannot be simply ignored. Rather, continued vigilance in the post-surgical setting for bleeding events that may be associated with the development of acquired coagulation factor inhibitors following bovine thrombin administration is warranted.</p> |
| first_indexed | 2024-04-12T16:15:43Z |
| format | Article |
| id | doaj.art-c913ed9b6c1d4e5381e62dcf058e0f55 |
| institution | Directory Open Access Journal |
| issn | 1754-9493 |
| language | English |
| last_indexed | 2024-04-12T16:15:43Z |
| publishDate | 2008-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Patient Safety in Surgery |
| spelling | doaj.art-c913ed9b6c1d4e5381e62dcf058e0f552022-12-22T03:25:43ZengBMCPatient Safety in Surgery1754-94932008-09-01212310.1186/1754-9493-2-23The unresolved safety concerns of bovine thrombinJavidroozi MazyarShander Aryeh<p>Abstract</p> <p>A recent review has suggested that bovine thrombin is not associated with an increased risk of bleeding in surgical populations. In spite of extremely limited evidence available, many valuable resources (e.g. safety surveillance and post-marketing programs, case reports) were excluded in reaching this conclusion. While waiting for the adequately powered, controlled clinical trials to address the effects of bovine thrombin on bleeding and thrombotic events, the potential risk cannot be simply ignored. Rather, continued vigilance in the post-surgical setting for bleeding events that may be associated with the development of acquired coagulation factor inhibitors following bovine thrombin administration is warranted.</p>http://www.pssjournal.com/content/2/1/23 |
| spellingShingle | Javidroozi Mazyar Shander Aryeh The unresolved safety concerns of bovine thrombin Patient Safety in Surgery |
| title | The unresolved safety concerns of bovine thrombin |
| title_full | The unresolved safety concerns of bovine thrombin |
| title_fullStr | The unresolved safety concerns of bovine thrombin |
| title_full_unstemmed | The unresolved safety concerns of bovine thrombin |
| title_short | The unresolved safety concerns of bovine thrombin |
| title_sort | unresolved safety concerns of bovine thrombin |
| url | http://www.pssjournal.com/content/2/1/23 |
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