Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation
Epilepsy is a common chronic neurological disorder related to genetic factors. Base on the non-integrating episomal vector technique, a human induced pluripotent stem cell (iPSC) line, termed as LZUSHI001-A, was generated from peripheral blood mononuclear cells (PBMCs) of a 11-year-old male patient...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506122001179 |
| _version_ | 1828848212749844480 |
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| author | Ya-Qing Liu Tiao-Wen Ling Hong-Yan Wang Yan-Hong Yang Wen-jun Song Tian-Cheng Wang |
| author_facet | Ya-Qing Liu Tiao-Wen Ling Hong-Yan Wang Yan-Hong Yang Wen-jun Song Tian-Cheng Wang |
| author_sort | Ya-Qing Liu |
| collection | DOAJ |
| description | Epilepsy is a common chronic neurological disorder related to genetic factors. Base on the non-integrating episomal vector technique, a human induced pluripotent stem cell (iPSC) line, termed as LZUSHI001-A, was generated from peripheral blood mononuclear cells (PBMCs) of a 11-year-old male patient with Epilepsy, who had a heterozygous (c.2042G>A, p.R681Q) mutation in the DGKG gene. LZUSHI001-A offers a useful resource to investigate pathogenic mechanisms in epilepsy, as well as a cell-based model for drug development to treat epilepsy. |
| first_indexed | 2024-12-12T22:24:30Z |
| format | Article |
| id | doaj.art-c914749d6b784d0b9be573415db25a51 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-12-12T22:24:30Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-c914749d6b784d0b9be573415db25a512022-12-22T00:09:48ZengElsevierStem Cell Research1873-50612022-05-0161102768Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutationYa-Qing Liu0Tiao-Wen Ling1Hong-Yan Wang2Yan-Hong Yang3Wen-jun Song4Tian-Cheng Wang5Department of Neurology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, ChinaDepartment of Neurology, The First People’s Hospital of Lanzhou City, Lanzhou 730050, Gansu Province, ChinaDepartment of Pediatric Neurology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou 730050, Gansu Province, ChinaDepartment of Neurology, Hangzhou Xiaoshan District First People's Hospital, Hangzhou 311200, Zhejiang Province, ChinaDepartment of Neurology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, ChinaDepartment of Neurology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China; Corresponding author.Epilepsy is a common chronic neurological disorder related to genetic factors. Base on the non-integrating episomal vector technique, a human induced pluripotent stem cell (iPSC) line, termed as LZUSHI001-A, was generated from peripheral blood mononuclear cells (PBMCs) of a 11-year-old male patient with Epilepsy, who had a heterozygous (c.2042G>A, p.R681Q) mutation in the DGKG gene. LZUSHI001-A offers a useful resource to investigate pathogenic mechanisms in epilepsy, as well as a cell-based model for drug development to treat epilepsy.http://www.sciencedirect.com/science/article/pii/S1873506122001179 |
| spellingShingle | Ya-Qing Liu Tiao-Wen Ling Hong-Yan Wang Yan-Hong Yang Wen-jun Song Tian-Cheng Wang Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation Stem Cell Research |
| title | Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation |
| title_full | Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation |
| title_fullStr | Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation |
| title_full_unstemmed | Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation |
| title_short | Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation |
| title_sort | generation of an integration free induced pluripotent stem cell line lzushi001 a from an epileptic patient with dgkg mutation |
| url | http://www.sciencedirect.com/science/article/pii/S1873506122001179 |
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