Development of KEAP1-targeting PROTAC and its antioxidant properties: In vitro and in vivo

Development of KEAP1-targeting PROTAC and its antioxidant properties: In vitro and in vivo

Oxidative stress due to abnormal accumulation of reactive oxygen species (ROS) is an initiator of a large number of human diseases, and thus, the elimination and prevention of excessive ROS are important aspects of preventing the development of such diseases. Nuclear factor erythroid 2-related facto...

Full description

Bibliographic Details
Main Authors: Se Yong Park, Raju Gurung, Jung Ho Hwang, Ju-Hee Kang, Hyun Jin Jung, Alam Zeb, Jong-Ik Hwang, Sung Jean Park, Han-Joo Maeng, Dongyun Shin, Seung Hyun Oh
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Redox Biology
Subjects:
Proteolysis-targeting chimera (PROTAC)
KEAP1
NRF2
Oxidative stress
Liver
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001842

Internet

http://www.sciencedirect.com/science/article/pii/S2213231723001842

Similar Items