In Vivo Visual Screen for Dopaminergic Rab ↔ LRRK2-G2019S Interactions in Drosophila Discriminates Rab10 from Rab3

In Vivo Visual Screen for Dopaminergic Rab ↔ LRRK2-G2019S Interactions in Drosophila Discriminates Rab10 from Rab3

LRRK2 mutations cause Parkinson’s, but the molecular link from increased kinase activity to pathological neurodegeneration remains undetermined. Previous in vitro assays indicate that LRRK2 substrates include at least 8 Rab GTPases. We have now examined this hypothesis in vivo in a functional, elect...

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Bibliographic Details
Main Authors: Stavroula Petridi, C. Adam Middleton, Chris Ugbode, Alison Fellgett, Laura Covill, Christopher J. H. Elliott
Format: Article
Language:English
Published: Oxford University Press 2020-06-01
Series:G3: Genes, Genomes, Genetics
Subjects:
lrrk2
g2019s
rab10
rab3
drosophila melanogaster
parkinson’s disease
parkinson’s uk k-1704 g-1804
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.120.401289

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