Interaction between gut microbiota and immune checkpoint inhibitor-related colitis
Immune checkpoint inhibitors (ICIs) have become a promising therapeutic strategy for malignant tumors, improving patient prognosis, along with a spectrum of immune-related adverse events (irAEs), including gastrointestinal toxicity, ICI-related colitis (IRC), and diarrhea. The gut microbiota has bee...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1001623/full |
| _version_ | 1811336102073597952 |
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| author | Guanzhou Zhou Guanzhou Zhou Nana Zhang Nana Zhang Ke Meng Fei Pan |
| author_facet | Guanzhou Zhou Guanzhou Zhou Nana Zhang Nana Zhang Ke Meng Fei Pan |
| author_sort | Guanzhou Zhou |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) have become a promising therapeutic strategy for malignant tumors, improving patient prognosis, along with a spectrum of immune-related adverse events (irAEs), including gastrointestinal toxicity, ICI-related colitis (IRC), and diarrhea. The gut microbiota has been suggested as an important regulator in the pathogenesis of IRC, and microbiota modulations like probiotics and fecal microbiota transplantation have been explored to treat the disease. This review discusses the interaction between the gut microbiota and IRC, focusing on the potential pathogenic mechanisms and promising interventions. |
| first_indexed | 2024-04-13T17:33:38Z |
| format | Article |
| id | doaj.art-c9160c1d24454a4dbc40b7a382b1dd2d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T17:33:38Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c9160c1d24454a4dbc40b7a382b1dd2d2022-12-22T02:37:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.10016231001623Interaction between gut microbiota and immune checkpoint inhibitor-related colitisGuanzhou Zhou0Guanzhou Zhou1Nana Zhang2Nana Zhang3Ke Meng4Fei Pan5Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaImmune checkpoint inhibitors (ICIs) have become a promising therapeutic strategy for malignant tumors, improving patient prognosis, along with a spectrum of immune-related adverse events (irAEs), including gastrointestinal toxicity, ICI-related colitis (IRC), and diarrhea. The gut microbiota has been suggested as an important regulator in the pathogenesis of IRC, and microbiota modulations like probiotics and fecal microbiota transplantation have been explored to treat the disease. This review discusses the interaction between the gut microbiota and IRC, focusing on the potential pathogenic mechanisms and promising interventions. https://www.frontiersin.org/articles/10.3389/fimmu.2022.1001623/fullimmune checkpoint inhibitorgut microbiotacolitisdiarrheamicrobiome |
| spellingShingle | Guanzhou Zhou Guanzhou Zhou Nana Zhang Nana Zhang Ke Meng Fei Pan Interaction between gut microbiota and immune checkpoint inhibitor-related colitis Frontiers in Immunology immune checkpoint inhibitor gut microbiota colitis diarrhea microbiome |
| title | Interaction between gut microbiota and immune checkpoint inhibitor-related colitis |
| title_full | Interaction between gut microbiota and immune checkpoint inhibitor-related colitis |
| title_fullStr | Interaction between gut microbiota and immune checkpoint inhibitor-related colitis |
| title_full_unstemmed | Interaction between gut microbiota and immune checkpoint inhibitor-related colitis |
| title_short | Interaction between gut microbiota and immune checkpoint inhibitor-related colitis |
| title_sort | interaction between gut microbiota and immune checkpoint inhibitor related colitis |
| topic | immune checkpoint inhibitor gut microbiota colitis diarrhea microbiome |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1001623/full |
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