PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling

PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling

Human cytomegalovirus (HCMV) infects 40–70% of adults in developed countries. HCMV proteins and DNA are detected in tumors and metastases, suggesting an association with increased invasion. We investigated HCMV infection in human breast cancer cell lines compared to fibroblasts, a component of tumor...

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Bibliographic Details
Main Authors: Zelei Yang, Xiaoyun Tang, Todd P. W. McMullen, David N. Brindley, Denise G. Hemmings
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
autotaxin
chemokines
cytokines
lipid phosphate phosphatases
lysophosphatidic acid
Online Access:https://www.mdpi.com/1422-0067/22/18/9817

Internet

https://www.mdpi.com/1422-0067/22/18/9817

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