Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter
Transforming growth factor β (TGF-β) is a well-known growth inhibitor of normal epithelial cells, but it is also secreted by solid tumors to promote cancer progression. Our recent discovery of SMAD3-PCBP1 complex with direct RNA-binding properties has shed light on how this conversion is implemented...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2016.1265699 |
| _version_ | 1797677238807691264 |
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| author | Veenu Tripathi Ying E. Zhang |
| author_facet | Veenu Tripathi Ying E. Zhang |
| author_sort | Veenu Tripathi |
| collection | DOAJ |
| description | Transforming growth factor β (TGF-β) is a well-known growth inhibitor of normal epithelial cells, but it is also secreted by solid tumors to promote cancer progression. Our recent discovery of SMAD3-PCBP1 complex with direct RNA-binding properties has shed light on how this conversion is implemented by controlling pre-mRNA splicing patterns. |
| first_indexed | 2024-03-11T22:42:10Z |
| format | Article |
| id | doaj.art-c917c82d5eaf43ed8762c4bfd3e2cea5 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:42:10Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-c917c82d5eaf43ed8762c4bfd3e2cea52023-09-22T09:10:57ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-01-014110.1080/23723556.2016.12656991265699Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoterVeenu Tripathi0Ying E. Zhang1Center for Cancer Research, National Cancer InstituteCenter for Cancer Research, National Cancer InstituteTransforming growth factor β (TGF-β) is a well-known growth inhibitor of normal epithelial cells, but it is also secreted by solid tumors to promote cancer progression. Our recent discovery of SMAD3-PCBP1 complex with direct RNA-binding properties has shed light on how this conversion is implemented by controlling pre-mRNA splicing patterns.http://dx.doi.org/10.1080/23723556.2016.1265699alternative splicingemtmetastasispcbp1smad3tgf-β |
| spellingShingle | Veenu Tripathi Ying E. Zhang Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter Molecular & Cellular Oncology alternative splicing emt metastasis pcbp1 smad3 tgf-β |
| title | Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter |
| title_full | Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter |
| title_fullStr | Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter |
| title_full_unstemmed | Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter |
| title_short | Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter |
| title_sort | redirecting rna splicing by smad3 turns tgf β into a tumor promoter |
| topic | alternative splicing emt metastasis pcbp1 smad3 tgf-β |
| url | http://dx.doi.org/10.1080/23723556.2016.1265699 |
| work_keys_str_mv | AT veenutripathi redirectingrnasplicingbysmad3turnstgfbintoatumorpromoter AT yingezhang redirectingrnasplicingbysmad3turnstgfbintoatumorpromoter |