Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway
Abstract Background Experimental autoimmune encephalomyelitis (EAE) is an animal disease model of multiple sclerosis (MS) that involves the immune system and central nervous system (CNS). However, it is unclear how genetic predispositions promote neuroinflammation in MS and EAE. Here, we investigate...
Main Authors: | Ruo-Nan Duan, Chun-Lin Yang, Tong Du, Ai Liu, An-Ran Wang, Wen-Jie Sun, Xi Li, Jiang-Xia Li, Chuan-Zhu Yan, Qi-Ji Liu |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-06-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12974-021-02193-0 |
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