Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function
Abstract Dissolving microneedles (DMNs) represent an innovative advancement in drug delivery and skincare technologies, offering significant advantages compared to traditional needles. This paper presents an overview of the historical evolution of microneedles and the rise of dissolving types, explo...
| Main Authors: | , , , |
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| 格式: | 文件 |
| 语言: | English |
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SpringerOpen
2024-08-01
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| 丛编: | Micro and Nano Systems Letters |
| 主题: | |
| 在线阅读: | https://doi.org/10.1186/s40486-024-00204-2 |
| _version_ | 1827139237203410944 |
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| author | Roshan Dave Swapnali Shinde Nisha Kalayil Aarati Budar |
| author_facet | Roshan Dave Swapnali Shinde Nisha Kalayil Aarati Budar |
| author_sort | Roshan Dave |
| collection | DOAJ |
| description | Abstract Dissolving microneedles (DMNs) represent an innovative advancement in drug delivery and skincare technologies, offering significant advantages compared to traditional needles. This paper presents an overview of the historical evolution of microneedles and the rise of dissolving types, exploring their definition, concept, and diverse clinical applications such as vaccinations, drug delivery, and skincare treatments. Design and manufacturing considerations cover the materials employed, fabrication techniques, and methods for characterizing DMNs, focusing on aspects like mechanical strength, dissolution rate, and delivery efficiency. The mechanism of action section examines skin penetration mechanics, the process of microneedle dissolution, controlled release of active compounds, and considerations of biocompatibility and safety. Recent developments in DMNs encompass technological advancements, improved delivery systems, and updates on clinical trials and studies. Challenges and opportunities in scaling up production, overcoming market adoption barriers, and future research directions are discussed, aiming to address unmet medical needs and expand applications. In summary, DMNs have the potential to transform drug delivery and skincare treatments, with ongoing advancements aimed at tackling current challenges and unlocking new opportunities for enhanced healthcare outcomes. Graphical Abstract |
| first_indexed | 2025-03-20T18:36:03Z |
| format | Article |
| id | doaj.art-c91ce27deb2f4b51a5a7249f98a4f77f |
| institution | Directory Open Access Journal |
| issn | 2213-9621 |
| language | English |
| last_indexed | 2025-03-20T18:36:03Z |
| publishDate | 2024-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Micro and Nano Systems Letters |
| spelling | doaj.art-c91ce27deb2f4b51a5a7249f98a4f77f2024-08-25T11:29:42ZengSpringerOpenMicro and Nano Systems Letters2213-96212024-08-0112111110.1186/s40486-024-00204-2Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and functionRoshan Dave0Swapnali Shinde1Nisha Kalayil2Aarati Budar3AETs St. John Institute of Pharmacy and ResearchAETs St. John Institute of Pharmacy and ResearchAETs St. John Institute of Pharmacy and ResearchAETs St. John Institute of Pharmacy and ResearchAbstract Dissolving microneedles (DMNs) represent an innovative advancement in drug delivery and skincare technologies, offering significant advantages compared to traditional needles. This paper presents an overview of the historical evolution of microneedles and the rise of dissolving types, exploring their definition, concept, and diverse clinical applications such as vaccinations, drug delivery, and skincare treatments. Design and manufacturing considerations cover the materials employed, fabrication techniques, and methods for characterizing DMNs, focusing on aspects like mechanical strength, dissolution rate, and delivery efficiency. The mechanism of action section examines skin penetration mechanics, the process of microneedle dissolution, controlled release of active compounds, and considerations of biocompatibility and safety. Recent developments in DMNs encompass technological advancements, improved delivery systems, and updates on clinical trials and studies. Challenges and opportunities in scaling up production, overcoming market adoption barriers, and future research directions are discussed, aiming to address unmet medical needs and expand applications. In summary, DMNs have the potential to transform drug delivery and skincare treatments, with ongoing advancements aimed at tackling current challenges and unlocking new opportunities for enhanced healthcare outcomes. Graphical Abstracthttps://doi.org/10.1186/s40486-024-00204-2Dissolving microneedlesDrug deliveryBiocompatibilityMicromoldingDrawing lithographyCentrifugal lithography |
| spellingShingle | Roshan Dave Swapnali Shinde Nisha Kalayil Aarati Budar Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function Micro and Nano Systems Letters Dissolving microneedles Drug delivery Biocompatibility Micromolding Drawing lithography Centrifugal lithography |
| title | Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function |
| title_full | Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function |
| title_fullStr | Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function |
| title_full_unstemmed | Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function |
| title_short | Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function |
| title_sort | engineering microscopic delivery systems a review of dissolving microneedle design fabrication and function |
| topic | Dissolving microneedles Drug delivery Biocompatibility Micromolding Drawing lithography Centrifugal lithography |
| url | https://doi.org/10.1186/s40486-024-00204-2 |
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