Potential Imaging Biomarkers of Cognitive Frailty
Cognitive frailty (CF) is a state of impairment in both cognitive and motor functions. The concept of CF has been developed in several ways. However, it is difficult to identify consistent neuroimaging findings according to the application of the operational definition of different frailty models wi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Korea Geriatrics Society
2023-03-01
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| Series: | Annals of Geriatric Medicine and Research |
| Subjects: | |
| Online Access: | http://www.e-agmr.org/upload/pdf/agmr-22-0141.pdf |
| _version_ | 1827972888338104320 |
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| author | Jaesub Park Woo Jung Kim |
| author_facet | Jaesub Park Woo Jung Kim |
| author_sort | Jaesub Park |
| collection | DOAJ |
| description | Cognitive frailty (CF) is a state of impairment in both cognitive and motor functions. The concept of CF has been developed in several ways. However, it is difficult to identify consistent neuroimaging findings according to the application of the operational definition of different frailty models within the same concept, as well as the diversity of the concept itself of CF. This study aimed to review neuroimaging studies of CF and to determine suitable imaging biomarkers of CF. White matter abnormalities (e.g., white matter hyperintensity and microbleeds) seem likely to be considered imaging biomarkers of CF. The volume of the cerebral/cerebellar cortex and that of the subcortical nuclei are also candidates of imaging biomarkers of CF. These imaging biomarkers are expected to be more useful in discriminating the need for screening CF in visitors of clinics or health examination centers than in detecting the presence of CF in community-dwelling older adults. |
| first_indexed | 2024-04-09T19:27:05Z |
| format | Article |
| id | doaj.art-c91d1f3cca4c41819c07d741c614ebcb |
| institution | Directory Open Access Journal |
| issn | 2508-4798 2508-4909 |
| language | English |
| last_indexed | 2024-04-09T19:27:05Z |
| publishDate | 2023-03-01 |
| publisher | Korea Geriatrics Society |
| record_format | Article |
| series | Annals of Geriatric Medicine and Research |
| spelling | doaj.art-c91d1f3cca4c41819c07d741c614ebcb2023-04-05T06:52:52ZengKorea Geriatrics SocietyAnnals of Geriatric Medicine and Research2508-47982508-49092023-03-012713810.4235/agmr.22.01411048Potential Imaging Biomarkers of Cognitive FrailtyJaesub Park0Woo Jung Kim1 Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, Korea Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, KoreaCognitive frailty (CF) is a state of impairment in both cognitive and motor functions. The concept of CF has been developed in several ways. However, it is difficult to identify consistent neuroimaging findings according to the application of the operational definition of different frailty models within the same concept, as well as the diversity of the concept itself of CF. This study aimed to review neuroimaging studies of CF and to determine suitable imaging biomarkers of CF. White matter abnormalities (e.g., white matter hyperintensity and microbleeds) seem likely to be considered imaging biomarkers of CF. The volume of the cerebral/cerebellar cortex and that of the subcortical nuclei are also candidates of imaging biomarkers of CF. These imaging biomarkers are expected to be more useful in discriminating the need for screening CF in visitors of clinics or health examination centers than in detecting the presence of CF in community-dwelling older adults.http://www.e-agmr.org/upload/pdf/agmr-22-0141.pdfcognitive frailtymotoric cognitive risk syndromephysio-cognitive decline syndromeimaging biomarkermagnetic resonance imaging |
| spellingShingle | Jaesub Park Woo Jung Kim Potential Imaging Biomarkers of Cognitive Frailty Annals of Geriatric Medicine and Research cognitive frailty motoric cognitive risk syndrome physio-cognitive decline syndrome imaging biomarker magnetic resonance imaging |
| title | Potential Imaging Biomarkers of Cognitive Frailty |
| title_full | Potential Imaging Biomarkers of Cognitive Frailty |
| title_fullStr | Potential Imaging Biomarkers of Cognitive Frailty |
| title_full_unstemmed | Potential Imaging Biomarkers of Cognitive Frailty |
| title_short | Potential Imaging Biomarkers of Cognitive Frailty |
| title_sort | potential imaging biomarkers of cognitive frailty |
| topic | cognitive frailty motoric cognitive risk syndrome physio-cognitive decline syndrome imaging biomarker magnetic resonance imaging |
| url | http://www.e-agmr.org/upload/pdf/agmr-22-0141.pdf |
| work_keys_str_mv | AT jaesubpark potentialimagingbiomarkersofcognitivefrailty AT woojungkim potentialimagingbiomarkersofcognitivefrailty |