Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature
Inadequate resection margins in head and neck squamous cell carcinoma surgery necessitate adjuvant therapies such as re-resection and radiotherapy with or without chemotherapy and imply increasing morbidity and worse prognosis. On the other hand, taking larger margins by extending the resection also...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/3/896 |
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| author | Bertram J. de Kleijn Gijs T. N. Heldens Jasmijn M. Herruer Cornelis F. M. Sier Cesare Piazza Remco de Bree Orlando Guntinas-Lichius Luiz P. Kowalski Vincent Vander Poorten Juan P. Rodrigo Nina Zidar Cherie-Ann Nathan Raymond K. Tsang Pawel Golusinski Ashok R. Shaha Alfio Ferlito Robert P. Takes |
| author_facet | Bertram J. de Kleijn Gijs T. N. Heldens Jasmijn M. Herruer Cornelis F. M. Sier Cesare Piazza Remco de Bree Orlando Guntinas-Lichius Luiz P. Kowalski Vincent Vander Poorten Juan P. Rodrigo Nina Zidar Cherie-Ann Nathan Raymond K. Tsang Pawel Golusinski Ashok R. Shaha Alfio Ferlito Robert P. Takes |
| author_sort | Bertram J. de Kleijn |
| collection | DOAJ |
| description | Inadequate resection margins in head and neck squamous cell carcinoma surgery necessitate adjuvant therapies such as re-resection and radiotherapy with or without chemotherapy and imply increasing morbidity and worse prognosis. On the other hand, taking larger margins by extending the resection also leads to avoidable increased morbidity. Oropharyngeal squamous cell carcinomas (OPSCCs) are often difficult to access; resections are limited by anatomy and functionality and thus carry an increased risk for close or positive margins. Therefore, there is a need to improve intraoperative assessment of resection margins. Several intraoperative techniques are available, but these often lead to prolonged operative time and are only suitable for a subgroup of patients. In recent years, new diagnostic tools have been the subject of investigation. This study reviews the available literature on intraoperative techniques to improve resection margins for OPSCCs. A literature search was performed in Embase, PubMed, and Cochrane. Narrow band imaging (NBI), high-resolution microendoscopic imaging, confocal laser endomicroscopy, frozen section analysis (FSA), ultrasound (US), computed tomography scan (CT), (auto) fluorescence imaging (FI), and augmented reality (AR) have all been used for OPSCC. NBI, FSA, and US are most commonly used and increase the rate of negative margins. Other techniques will become available in the future, of which fluorescence imaging has high potential for use with OPSCC. |
| first_indexed | 2024-03-11T09:50:27Z |
| format | Article |
| id | doaj.art-c91e24baf71e45a78d546fe1df343648 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:50:27Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c91e24baf71e45a78d546fe1df3436482023-11-16T16:18:51ZengMDPI AGCancers2072-66942023-01-0115389610.3390/cancers15030896Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current LiteratureBertram J. de Kleijn0Gijs T. N. Heldens1Jasmijn M. Herruer2Cornelis F. M. Sier3Cesare Piazza4Remco de Bree5Orlando Guntinas-Lichius6Luiz P. Kowalski7Vincent Vander Poorten8Juan P. Rodrigo9Nina Zidar10Cherie-Ann Nathan11Raymond K. Tsang12Pawel Golusinski13Ashok R. Shaha14Alfio Ferlito15Robert P. Takes16Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, 6225 GA Nijmegen, The NetherlandsDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, 6225 GA Nijmegen, The NetherlandsDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, 6225 GA Nijmegen, The NetherlandsDepartment of Oncologic Surgery, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsUnit of Otorhinolaryngology—Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25123 Brescia, ItalyDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Otorhinolaryngology, Jena University Hospital, 07747 Jena, GermanyDepartment of Head and Neck Surgery, University of Sao Paulo Medical School, Sao Paulo 01509, BrazilDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, 33011 Oviedo, SpainInstitute of Pathology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaDepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University-Health Shreveport, Shreveport, LA 71101, USADepartment of Otolaryngology-Head and Neck Surgery, National University of Singapore, Level 7 Tower Block, National University Hospital, 1E Kent Ridge Road, Singapore 119228, SingaporeDepartment of Otolaryngology and Maxillofacial Surgery, University of Zielona Gora, 65-417 Zielona Gora, PolandHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USACoordinator of the International Head and Neck Scientific Group, 35122 Padua, ItalyDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, 6225 GA Nijmegen, The NetherlandsInadequate resection margins in head and neck squamous cell carcinoma surgery necessitate adjuvant therapies such as re-resection and radiotherapy with or without chemotherapy and imply increasing morbidity and worse prognosis. On the other hand, taking larger margins by extending the resection also leads to avoidable increased morbidity. Oropharyngeal squamous cell carcinomas (OPSCCs) are often difficult to access; resections are limited by anatomy and functionality and thus carry an increased risk for close or positive margins. Therefore, there is a need to improve intraoperative assessment of resection margins. Several intraoperative techniques are available, but these often lead to prolonged operative time and are only suitable for a subgroup of patients. In recent years, new diagnostic tools have been the subject of investigation. This study reviews the available literature on intraoperative techniques to improve resection margins for OPSCCs. A literature search was performed in Embase, PubMed, and Cochrane. Narrow band imaging (NBI), high-resolution microendoscopic imaging, confocal laser endomicroscopy, frozen section analysis (FSA), ultrasound (US), computed tomography scan (CT), (auto) fluorescence imaging (FI), and augmented reality (AR) have all been used for OPSCC. NBI, FSA, and US are most commonly used and increase the rate of negative margins. Other techniques will become available in the future, of which fluorescence imaging has high potential for use with OPSCC.https://www.mdpi.com/2072-6694/15/3/896intraoperative imagingnarrow band imaginghigh resolution microendoscopic imagingconfocal laser endomicroscopyultrasound(auto) fluorescence imaging |
| spellingShingle | Bertram J. de Kleijn Gijs T. N. Heldens Jasmijn M. Herruer Cornelis F. M. Sier Cesare Piazza Remco de Bree Orlando Guntinas-Lichius Luiz P. Kowalski Vincent Vander Poorten Juan P. Rodrigo Nina Zidar Cherie-Ann Nathan Raymond K. Tsang Pawel Golusinski Ashok R. Shaha Alfio Ferlito Robert P. Takes Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature Cancers intraoperative imaging narrow band imaging high resolution microendoscopic imaging confocal laser endomicroscopy ultrasound (auto) fluorescence imaging |
| title | Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature |
| title_full | Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature |
| title_fullStr | Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature |
| title_full_unstemmed | Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature |
| title_short | Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature |
| title_sort | intraoperative imaging techniques to improve surgical resection margins of oropharyngeal squamous cell cancer a comprehensive review of current literature |
| topic | intraoperative imaging narrow band imaging high resolution microendoscopic imaging confocal laser endomicroscopy ultrasound (auto) fluorescence imaging |
| url | https://www.mdpi.com/2072-6694/15/3/896 |
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