The Role of Adipokines in the Pathogenesis of Psoriasis
Psoriasis is a chronic and immune-mediated skin condition characterized by pro-inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes, and keratinocytes represent the main cell subtypes involved in the pathogenesis of psoriasis, while the interleukin-23 (IL-23)/IL...
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/7/6390 |
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| author | Kajetan Kiełbowski Estera Bakinowska Piotr Ostrowski Bartłomiej Pala Ewa Gromowska Klaudia Gurazda Paweł Dec Andrzej Modrzejewski Andrzej Pawlik |
| author_facet | Kajetan Kiełbowski Estera Bakinowska Piotr Ostrowski Bartłomiej Pala Ewa Gromowska Klaudia Gurazda Paweł Dec Andrzej Modrzejewski Andrzej Pawlik |
| author_sort | Kajetan Kiełbowski |
| collection | DOAJ |
| description | Psoriasis is a chronic and immune-mediated skin condition characterized by pro-inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes, and keratinocytes represent the main cell subtypes involved in the pathogenesis of psoriasis, while the interleukin-23 (IL-23)/IL-17 pathway enhances the disease progression. Human adipose tissue is an endocrine organ, which secretes multiple proteins, known as adipokines, such as adiponectin, leptin, visfatin, or resistin. Current evidence highlights the immunomodulatory roles of adipokines, which may contribute to the progression or suppression of psoriasis. A better understanding of the complexity of psoriasis pathophysiology linked with adipokines could result in developing novel diagnostic or therapeutic strategies. This review aims to present the pathogenesis of psoriasis and the roles of adipokines in this process. |
| first_indexed | 2024-03-11T05:35:15Z |
| format | Article |
| id | doaj.art-c91e91e6f9e549da8f6e9fb5bf37618c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:35:15Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c91e91e6f9e549da8f6e9fb5bf37618c2023-11-17T16:50:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01247639010.3390/ijms24076390The Role of Adipokines in the Pathogenesis of PsoriasisKajetan Kiełbowski0Estera Bakinowska1Piotr Ostrowski2Bartłomiej Pala3Ewa Gromowska4Klaudia Gurazda5Paweł Dec6Andrzej Modrzejewski7Andrzej Pawlik8Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandPlastic and Reconstructive Surgery Department, 109 Military Hospital, 71-422 Szczecin, PolandDepartment of Surgery, Pomeranian Medical University, 71-422 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandPsoriasis is a chronic and immune-mediated skin condition characterized by pro-inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes, and keratinocytes represent the main cell subtypes involved in the pathogenesis of psoriasis, while the interleukin-23 (IL-23)/IL-17 pathway enhances the disease progression. Human adipose tissue is an endocrine organ, which secretes multiple proteins, known as adipokines, such as adiponectin, leptin, visfatin, or resistin. Current evidence highlights the immunomodulatory roles of adipokines, which may contribute to the progression or suppression of psoriasis. A better understanding of the complexity of psoriasis pathophysiology linked with adipokines could result in developing novel diagnostic or therapeutic strategies. This review aims to present the pathogenesis of psoriasis and the roles of adipokines in this process.https://www.mdpi.com/1422-0067/24/7/6390psoriasisadipokinesleptinadiponectininflammationcytokines |
| spellingShingle | Kajetan Kiełbowski Estera Bakinowska Piotr Ostrowski Bartłomiej Pala Ewa Gromowska Klaudia Gurazda Paweł Dec Andrzej Modrzejewski Andrzej Pawlik The Role of Adipokines in the Pathogenesis of Psoriasis International Journal of Molecular Sciences psoriasis adipokines leptin adiponectin inflammation cytokines |
| title | The Role of Adipokines in the Pathogenesis of Psoriasis |
| title_full | The Role of Adipokines in the Pathogenesis of Psoriasis |
| title_fullStr | The Role of Adipokines in the Pathogenesis of Psoriasis |
| title_full_unstemmed | The Role of Adipokines in the Pathogenesis of Psoriasis |
| title_short | The Role of Adipokines in the Pathogenesis of Psoriasis |
| title_sort | role of adipokines in the pathogenesis of psoriasis |
| topic | psoriasis adipokines leptin adiponectin inflammation cytokines |
| url | https://www.mdpi.com/1422-0067/24/7/6390 |
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