BEYOND THE ‘PAIN MATRIX’, INTER-RUN SYNCHRONIZATION DURING MECHANICAL NOCICEPTIVE STIMULATION
Pain is a complex experience that emerges from the activity multiple brain areas, some of which are inconsistently detected using traditional fMRI analysis. One hypothesis is that the traditional analysis of pain-related response, by relying on the correlation of a predictor convolved with the canon...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00265/full |
| _version_ | 1828155706764689408 |
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| author | Franco eCauda Franco eCauda Tommaso eCosta Tommaso eCosta Matteo eDiano Matteo eDiano Sergio eDuca Diana M.E. Torta Diana M.E. Torta |
| author_facet | Franco eCauda Franco eCauda Tommaso eCosta Tommaso eCosta Matteo eDiano Matteo eDiano Sergio eDuca Diana M.E. Torta Diana M.E. Torta |
| author_sort | Franco eCauda |
| collection | DOAJ |
| description | Pain is a complex experience that emerges from the activity multiple brain areas, some of which are inconsistently detected using traditional fMRI analysis. One hypothesis is that the traditional analysis of pain-related response, by relying on the correlation of a predictor convolved with the canonical hemodynamic response function (HRF)- the general linear model (GLM)- may under-detect the activity of those areas involved in stimulus processing that do not present a canonical HRF. In this study, we employed an innovative data-driven processing approach- an inter-run synchronization analysis- that has the advantage of not establishing any pre-determined predictor definition. With this method we were able to evidence the involvement of several brain regions that are not usually found when using predictor-based analysis. These areas are synchronized during painful stimulation and are characterized by a BOLD response that differs from the canonical HRF. This finding opens to new approaches in the study of pain imaging. |
| first_indexed | 2024-04-11T22:57:41Z |
| format | Article |
| id | doaj.art-c9217b44530343f495e16c620494f4a2 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-11T22:57:41Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-c9217b44530343f495e16c620494f4a22022-12-22T03:58:19ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612014-05-01810.3389/fnhum.2014.0026551602BEYOND THE ‘PAIN MATRIX’, INTER-RUN SYNCHRONIZATION DURING MECHANICAL NOCICEPTIVE STIMULATIONFranco eCauda0Franco eCauda1Tommaso eCosta2Tommaso eCosta3Matteo eDiano4Matteo eDiano5Sergio eDuca6Diana M.E. Torta7Diana M.E. Torta8University of TurinKoelliker HospitalUniversity of TurinKoelliker HospitalUniversity of TurinKoelliker HospitalKoelliker HospitalUniversity of TurinKoelliker HospitalPain is a complex experience that emerges from the activity multiple brain areas, some of which are inconsistently detected using traditional fMRI analysis. One hypothesis is that the traditional analysis of pain-related response, by relying on the correlation of a predictor convolved with the canonical hemodynamic response function (HRF)- the general linear model (GLM)- may under-detect the activity of those areas involved in stimulus processing that do not present a canonical HRF. In this study, we employed an innovative data-driven processing approach- an inter-run synchronization analysis- that has the advantage of not establishing any pre-determined predictor definition. With this method we were able to evidence the involvement of several brain regions that are not usually found when using predictor-based analysis. These areas are synchronized during painful stimulation and are characterized by a BOLD response that differs from the canonical HRF. This finding opens to new approaches in the study of pain imaging.http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00265/fullPain MeasurementfMRIimagingGLMinter-run synchronization |
| spellingShingle | Franco eCauda Franco eCauda Tommaso eCosta Tommaso eCosta Matteo eDiano Matteo eDiano Sergio eDuca Diana M.E. Torta Diana M.E. Torta BEYOND THE ‘PAIN MATRIX’, INTER-RUN SYNCHRONIZATION DURING MECHANICAL NOCICEPTIVE STIMULATION Frontiers in Human Neuroscience Pain Measurement fMRI imaging GLM inter-run synchronization |
| title | BEYOND THE ‘PAIN MATRIX’, INTER-RUN SYNCHRONIZATION DURING MECHANICAL NOCICEPTIVE STIMULATION |
| title_full | BEYOND THE ‘PAIN MATRIX’, INTER-RUN SYNCHRONIZATION DURING MECHANICAL NOCICEPTIVE STIMULATION |
| title_fullStr | BEYOND THE ‘PAIN MATRIX’, INTER-RUN SYNCHRONIZATION DURING MECHANICAL NOCICEPTIVE STIMULATION |
| title_full_unstemmed | BEYOND THE ‘PAIN MATRIX’, INTER-RUN SYNCHRONIZATION DURING MECHANICAL NOCICEPTIVE STIMULATION |
| title_short | BEYOND THE ‘PAIN MATRIX’, INTER-RUN SYNCHRONIZATION DURING MECHANICAL NOCICEPTIVE STIMULATION |
| title_sort | beyond the pain matrix inter run synchronization during mechanical nociceptive stimulation |
| topic | Pain Measurement fMRI imaging GLM inter-run synchronization |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00265/full |
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