An oscillatory mechanism for multi-level storage in short-term memory
Abstract Oscillatory activity is commonly observed during the maintenance of information in short-term memory, but its role remains unclear. Non-oscillatory models of short-term memory storage are able to encode stimulus identity through their spatial patterns of activity, but are typically limited...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05200-7 |
| _version_ | 1797557238193192960 |
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| author | Kathleen P. Champion Olivia Gozel Benjamin S. Lankow G. Bard Ermentrout Mark S. Goldman |
| author_facet | Kathleen P. Champion Olivia Gozel Benjamin S. Lankow G. Bard Ermentrout Mark S. Goldman |
| author_sort | Kathleen P. Champion |
| collection | DOAJ |
| description | Abstract Oscillatory activity is commonly observed during the maintenance of information in short-term memory, but its role remains unclear. Non-oscillatory models of short-term memory storage are able to encode stimulus identity through their spatial patterns of activity, but are typically limited to either an all-or-none representation of stimulus amplitude or exhibit a biologically implausible exact-tuning condition. Here we demonstrate a simple mechanism by which oscillatory input enables a circuit to generate persistent or sequential activity that encodes information not only in the spatial pattern of activity, but also in the amplitude of activity. This is accomplished through a phase-locking phenomenon that permits many different amplitudes of persistent activity to be stored without requiring exact tuning of model parameters. Altogether, this work proposes a class of models for the storage of information in working memory, a potential role for brain oscillations, and a dynamical mechanism for maintaining multi-stable neural representations. |
| first_indexed | 2024-03-10T17:14:30Z |
| format | Article |
| id | doaj.art-c921fd0f8b4348d7a66df21b0ccd826b |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-10T17:14:30Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-c921fd0f8b4348d7a66df21b0ccd826b2023-11-20T10:33:46ZengNature PortfolioCommunications Biology2399-36422023-08-01611910.1038/s42003-023-05200-7An oscillatory mechanism for multi-level storage in short-term memoryKathleen P. Champion0Olivia Gozel1Benjamin S. Lankow2G. Bard Ermentrout3Mark S. Goldman4Department of Applied Mathematics, University of WashingtonDepartments of Neurobiology and Statistics, University of ChicagoCenter for Neuroscience, University of California, DavisDepartment of Mathematics, University of PittsburghCenter for Neuroscience, University of California, DavisAbstract Oscillatory activity is commonly observed during the maintenance of information in short-term memory, but its role remains unclear. Non-oscillatory models of short-term memory storage are able to encode stimulus identity through their spatial patterns of activity, but are typically limited to either an all-or-none representation of stimulus amplitude or exhibit a biologically implausible exact-tuning condition. Here we demonstrate a simple mechanism by which oscillatory input enables a circuit to generate persistent or sequential activity that encodes information not only in the spatial pattern of activity, but also in the amplitude of activity. This is accomplished through a phase-locking phenomenon that permits many different amplitudes of persistent activity to be stored without requiring exact tuning of model parameters. Altogether, this work proposes a class of models for the storage of information in working memory, a potential role for brain oscillations, and a dynamical mechanism for maintaining multi-stable neural representations.https://doi.org/10.1038/s42003-023-05200-7 |
| spellingShingle | Kathleen P. Champion Olivia Gozel Benjamin S. Lankow G. Bard Ermentrout Mark S. Goldman An oscillatory mechanism for multi-level storage in short-term memory Communications Biology |
| title | An oscillatory mechanism for multi-level storage in short-term memory |
| title_full | An oscillatory mechanism for multi-level storage in short-term memory |
| title_fullStr | An oscillatory mechanism for multi-level storage in short-term memory |
| title_full_unstemmed | An oscillatory mechanism for multi-level storage in short-term memory |
| title_short | An oscillatory mechanism for multi-level storage in short-term memory |
| title_sort | oscillatory mechanism for multi level storage in short term memory |
| url | https://doi.org/10.1038/s42003-023-05200-7 |
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